... Production, School of Veterinary Medicine, University of Messina, Messina, Italy3Department of Experimental and Clinical Medicine and Pharmacology, School of Medicine, University of Messina, Messina, ... activity of the glycosaminoglycans hyaluronic acid (HYA) and chondroitin-4-sulphate (C4S), weused a rat model of collagen-induced arthritis (CIA). Arthritis was induced in Lewis rats by multiple intradermal ... Homologoustype II collagen-induced arthritis in rats. Characterization of the disease and demonstration of clinically distinct forms of arthritis in two strains of rats after immunization with thesame...