... nutrient sensing in the brain and is an example of an enzyme that can sense and respond to the nutritional environment. The majorchallenge to understanding the role of CPT1c is todetermine its enzymatic ... adiposity. Based on these and other findings, metabolicintermediates in fatty acid biogenesis, including malonyl-CoA and long-chain acyl-CoAs, have been implicated as signaling mediators in the centralcontrol ... malonyl-CoA and CPT1c in the treatment of obesity Michael J. Wolfgang and M. Daniel LaneDepartment of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, MD, USAIntroductionAll...