... participated in the study design and interpretation of the data. JB participated in the study design and interpretation of the data. IDV partici-pated in the study design, interpretation of the data, and ... onset since adrenal and gonadal androgendeficiency can trigger inflammatory cytokines such as TNFα and IL-6, key cytokines responsible for the inflammatoryresponse in RA [25]. Alternatively, androgens ... polymorphisms in the NHS and the WHSFor ESR2, PGR and CYP19, none of the individual htSNPswere significantly associated with RA. A single haplotype in ESR2 and a single haplotype in PGR were...