... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinasedomain. The mutated residues are indicated in yellow, a-helices are in cyan, ... T-cell kinase (ITK) could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining ... Holland J, DaviesA, Flinter F, Hammarstrom L, Kinnon C, LevinskyR, Bobrow M et al. (1993) The gene involved in X-linked agammaglobulinaemia is a member of the srcfamily of protein-tyrosine kinases....