báo cáo khoa học: " Bridging the gap between systems biology and medicine" potx

... (Figure 1).A serious and useful dialogue between the clinic and systems biology has begun. We hope that future developments willprovide continuing evidence that the systems- biology community has ... as a translational extension of systems biology. How is systems medicinedefined? What are relevant ontologies for systems medicine? What are the key theoretic and methodologic challenges facing ... technologicadvances, fundamental obstacles separate systems biology from clinical applications. Bridging these gaps will require afocused and concerted effort. What defines systems medicineas a discipline? What...

Báo cáo khoa học: Bridging the gap between in silico and cell-based analysis of the nuclear factor-jB signaling pathway by in vitro studies of IKK2 ppt

... for binding GST-IjBa in the presence and absenceof ATP, and the value of a indicates whether the bindingof one substrate (ATP) affects the afﬁnity of the enzymefor the other substrate (GST-IjB ... and the plates left to incubate for15 min. The plates were inverted to remove the detergentafter the 15 min incubation period and the wells werewashed twice with wash buffer by inverting the ... prepared for cellassay and was added following the same procedure des-cribed for the time course cell assay. The cells were washedwith NaCl ⁄ Pi and ﬁxed after 400 min, and the standardimmunocytochemical...

báo cáo khoa học: " Bridging the gap between basic science and clinical practice: a role for community clinicians" pptx

... contributionsKK, MB, and GR designed the study and drafted the manuscript. EQ, CB, ST,MC, and HP guided study design and read and revised the manuscript. Allauthors have read and approved the final manuscript.Competing ... clinical trials:Hypothesis and designHypothesis and study questions are designed to improve the understanding of the mechanism by which an intervention worksHypothesis and study questions are ... contentchange between the early and the late interviews thatis specified in Table 2. The interview fi ndings and the literature review informed the development of a modelfor a program to recruit and...

báo cáo khoa học: "Bridging the gap between basic science and clinical practice: The role of organizations in addressing clinician barriers" pps

... USA.7Compass Lexecon, Oakland, CA, USA.Authors’ contributionsMB, GR, and KK designed the study and drafted the manuscript. EQ, CB, ST,MC, and HP guided study design and read and revised the manuscript. ... weregoing to start a research business. They walk in and anoint their office nurse study coordinator for the day.They do two trials and they look at each other and say,boy this is a whole lot harder ... self-reportinterviews. The RAND in stitutional review board (IRB) re viewedthese m aterials and procedures prior to the start of the interviews.Results The results of our initial interviews and literature...

báo cáo khoa học: " Bridging the gap between epigenetics research and nutritional public health interventions" pot

... level at any one time represents the equilibrium between the activities of Dnmts and demethylases such that a shift in the activities of these enzymes could alter the level of methylation even ... hypomethylation of and increased mRNA expression from the promoters of the GR and peroxisome proliferator-activated receptor α (PPARα) genes in the liver of the oﬀspring [14]. Hypo-methylation of the GR ... vulnerability in the regulation of this gene, and potentially of others. is is supported by the ﬁnding that the maternal PR diet induced a persistent change in 311 genes in the liver of the adult...

Tài liệu Báo cáo khoa học: "Bridging the Gap Between Underspeciﬁcation Formalisms: Minimal Recursion Semantics as Dominance Constraints" docx

... et al., 2003, Theorem 10.1).2. What is the precise relationship to other un-derspecification formalism? Are all of them the same, or else, what are the differences?We distinguish the sublanguages ... call of the solver,where L1 dominates L3 and L4. The solved form of the restricted graph is then put below the left hole ofL2, since it is connected to this hole. As a result, weobtain the solved ... fragments: Bridging the Gap Between Underspecification Formalisms:Minimal Recursion Semantics as Dominance ConstraintsJoachim NiehrenProgramming Systems LabUniversität des Saarlandesniehren@ps.uni-sb.deStefan...

Tài liệu Báo cáo khoa học: "Bridging the Gap Between Underspecification Formalisms: Hole Semantics as Dominance Constraints" ppt

... variables how they will be sit-uated in a solution of the solved form. They caneither dominate each other in either direction, orthey can be disjoint. But if they are disjoint, wealso know the lowest ... s.t. Fi E 0, the holes X1,1 and are different.0 is called the set of upper fragments of the chain, and QI is the set of lower fragments. We call all the Xj,1 and Xi,r connecting ... mapping each holeh to the label P(h ) in the USR, and mapping the new top hole 1/0 to the label denoting the root of the tree.6 From Solved Forms to ConstructiveSolutionsTheorem 4 establishes...

Báo cáo khoa học: "Bridging the Gap between Dictionary and Thesaurus" pptx

... B for the WN synsets and the ROGET classes. A simi- larity score B(j, k) is computed for the jth WN synset (taking the synset itself, the hypernyms, and the coordinate terms) and the k ... computed for the i th LDOCE sense and the jth WN synset using a weighted sum of the overlaps between the LDOCE sense and the WN synset, hypernyms, and gloss respectively, that is .4(i,j) ... no counterpart in the others, i.e. they were not at- tached to any links. Thus 18.9% of the LDOCE senses, 11.1% of the WN synsets and 58.1% of the ROGET classes were among these unattached...

Báo cáo khoa học: Probing the interface between factor Xa and tissue factor in the quaternary complex tissue factor–factor VIIa–factor Xa–tissue factor pathway inhibitor pptx

... spectra and in the rest of the mutants the probewas not signiﬁcantly affected by the sTF–FVIIa complexformation.As the purpose of our study was to map the interaction between FXa and sTF in the ... sTF and the effect of the modiﬁed sTF–FVIIacomplex on FX activation. In another study [17], theseauthors also examined the interaction between FXa and sTF–FVII in a similar way by observing the ... part of the TF2 domain and the C-terminal part of the TF1 domain, i.e. the residues 104 and 197, participates in the interaction withFXa in the quaternary complex. Moreover, comparisons of the interaction...

Báo cáo khoa học: "Probing the link between oestrogen receptors and oesophageal cancer" ppt

... currentunderstanding on the biological significance of ERs intumourigenesis has emerged from studies of breast can-cer and the relationship between the expression of ERa and response to the nonsteroidal ... the work has been based on immunohistochemistry and hasnot been validated with other available techniques. The inconsistencies in the published literature on the link between ER expression and ... principally via ERa and ERb firstcloned from rat prostate [32]. This discovery led to areappraisal and new perspective on the significance of the ER in health and disease. The ERa and ERb, isoformsare...

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