... rat models of paw edema and arthritic ankleAnalgesic and antiarthritic effects of piperine in rat models of paw edema and arthritic ankle. (a) Piperine showed analgesic effects in carrageenan-induced ... Newman RA, Aggarwal BB: Bioa-vailability of curcumin: problems and promises. Mol Pharm2007, 4:807-818.19. Iwashita M, Saito M, Yamaguchi Y, Takagaki R, Nakahata N: Inhib-itory effect of ethanol ... 9 days. With progression of arthritis, redness and swelling of the ankle joints and arthritic pain started toappear and reached a maximum on day 1 after the carra-geenan injection. At that...