... trig-gering receptor kinase activity and signaling pathwaysinvolving the binding of ezrin to ezrin–radixin–moesinproteins, and thus actin cytoskeleton binding and Rasactivation. HGF elicits metastatic ... [22,23]. The rather short cytoplasmic tail of CD44 binds to ankyrin and ezrin–radixin–moesinproteins, providing a link to the cytoskeleton, as well as to merlin, which abrogates this binding. However, the ... high-molecular-mass isoforms CD44v4–v7 and CD44v6–v9 in various cancers [45–52], as well as the downregula-tion of the CD44s isoform in colon cancer, has beenpostulated to result in increased tumorigenicity...