... overproduction of HA in cancer cells,such as fibrosarcomas, breast cancer, mesotheliomasand prostate cancer, transfected with HAS1, HAS2and HAS3 genes, triggered intracellular signaling path-ways ... responsible for maintaining thetumor and, possibly, for the formation of new tumorsat metastatic loci. CD44 has been identified as animportant marker of such a population of cancer stemcells in breast, ... known for its role inthe metastatic cascade, as this interaction regulatesthe ability of malignant cells to activate receptor tyro-sine kinases, and to stimulate migration, invasion ofbasement...