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Báo cáo y học: " Resveratrol retards progression of diabetic nephropathy through modulations of oxidative stress, proinflammatory cytokines, and AMP-activated protein kinase" potx

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Báo cáo y học: "Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients"

... withAPACHE II scores, SOFA scores or C-reactive protein (CRP)levels.Figure 1Box plots of results in healthy controls and study patientsBox plots of results in healthy controls and study patients. Circulat-ing ... severity of illness asassessed by injury severity score [22], organ failure index [24],Acute Physiology and Chronic Health Evaluation (APACHE) IIscores and Sequential Organ Failure Assessment (SOFA)scores ... pres-ence of low Ang-1 and VEGF; Ang-2 correlates with severity of illness (APACHE II and SOFA scores), pulmonary dysfunc-tion (PaO2/FiO2 and PaO2) and tissue hypoxia (lactate); usingmultivariate...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"

... science of statistics is increasingly employed in all fields of medicine. Statistical techniques are used not only byacademics and clinicians directly involved in medicalresearch but also by advocates ... themanagement of patients have a sound grasp of at least thebasics of statistical methods. Unfortunately, in practice this isoften not true, with many relying on distant memories of poorly understood ... presentation and summary of data. It is unlikely that the material covered bythis article will be entirely new to any reader but it is includedas a simple introduction to some of the ideas and philosophiesthat...
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Báo cáo y học: "Technical Considerations in Decompressive Craniectomy in the Treatment of Traumatic Brain Injury"

... e d b y loose closure of the dura and skin layers presum a b l y allows for expansion of the edematous brain into a durotomy “bag” under the loosely closed scalp without restriction by the ... Several types of decompressive craniectomy have been performed for the management of trau-matic refractory intracranial hypertension, and the variations in results between studies may be ex-plained ... valuable. At present, in the absence of de -finite proof of the efficacy of decompressive craniec-tomy in the treatment of TBI, such as from multicen-ter, prospective, randomized, controlled trials,...
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Báo cáo y học: " Self-reported sickness absence as a risk marker of future disability pension. Prospective findings from the DWECS/DREAM study 1990-2004"

... 154tervene and potentially prevent early disability pen-sion, we performed analysis for 4174 employees be-tween 18 and 45 years of age at study entry. 2. Methods The study is based upon ... generalizability of the results, and the findings may therefore not apply to the general population. The present study and the study by Gjesdal and Bratberg [10] are to our knowledge the only two stud-ies ... as they may be beneficiaries for decades: An upper cut-off point of 45 years of ages was chosen to ensure a study population considerably younger than the official retirement age, and to...
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Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients

... Introduction Cystatin C (Cys-C) is a non-glycosylated cationic protein of 13.3 kDa, belonging to the cystatin superfamily of cysteine protease inhibitors [1, 2]. Cys-C is produced by all nucleated ... terms of the estimation of pharmacokinetics of drugs. Here, the analysis was Int. J. Med. Sci. 2006, 3 94Figure 2. Relationships between serum levels of Cys-C and Cr in 56 healthy elderly ... 22-24], however, the effects of gender, age, circadian rhythm and muscle mass on the serum level of Cr, and the lower sensitivity of Cr for moderate renal dysfunction are often raised as being problematic....
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Tài liệu Báo cáo Y học: CK2btes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster potx

Tài liệu Báo cáo Y học: CK2btes gene encodes a testis-specific isoform of the regulatory subunit of casein kinase 2 in Drosophila melanogaster potx

... subunits shown in ou r yeast two-hybrid system experiments, it is reasonable to suppose apossibility of a replacement of one b subunit by another i nthe case of a deficiency of any of the subunits, ... mM).Fig. 3. Effect of polylysine on the phosphorylation of calmodulin bycatalytic subunit or by holoenzyme reconstituted from CK2a and CK2btes proteins. Calmodulin was phosphorylated in the presence(lanes ... 15%SDS/PAGE. The gels were dried and autoradiographed.Assays for detection of protein- protein contactsin yeast two-hybrid system Protein protein interactions were assayed using threedifferent approaches....
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Tài liệu Báo cáo Y học: Studies into factors contributing to substrate specificity of membrane-bound 3-ketoacyl-CoA synthases pot

Tài liệu Báo cáo Y học: Studies into factors contributing to substrate specificity of membrane-bound 3-ketoacyl-CoA synthases pot

... acyl-acyl carrier protein thioesterases and acyl-acyl carrier protein desaturases, adecrease in the activity of the engineered enzymes oftenresulted, regardless of a high level of identity ... level of activity found inmany of the chimeric enzymes. Many of the changes wemade resulted in chimeric enzymes with substantiallylower activity than the wild-type parents. This wasespecially ... of our work was to examine the substratespecificity of A. thaliana and B. napus FAE1 KCSs and tostudy the determinants of fatty acyl chain length specificityin 3-ketoacyl CoA condensing enzymes....
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Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

Tài liệu Báo cáo Y học: Interallelic recombination is probably responsible for the occurrence of a new as1-casein variant found in the goat species potx

... (fully), and Ser41 and Ser115 (partly), which originate in proteins withfive, six and seven phosphates/mol, explaining the hetero-geneity of phosphorylation observed for the n ative protein by ... Mediterranean a rea usuallydisplay a high f requency of ‘strong’ alleles (mainly A and B).However, local and now rare breeds generally do not followthis rule and are often the source of rare ‘germoplasms’.Three ... freeze-drying.Liquid chromatography/mass spectrometry analysis of proteins and peptidesThe whole caprine casein samples were fractionated by theprocedure of J aubert and M artin [21], modified by...
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Báo cáo Y học: O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines Distinct specificity of GalNAc-transferase isoforms pot

Báo cáo Y học: O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines Distinct specificity of GalNAc-transferase isoforms pot

... School of Pharmaceutical Sciences, The University of Tokyo,Japan;2Department of Oral Diagnostics, Faculty of Health Sciences, School of Dentistry, University of Copenhagen, DenmarkO-Glycosylation ... O-glycosylation; mucin; polypeptide N-acetylga-lactosaminyltransferase; Tn antigen; UDP-GalNAc.Biosynthesis of O-glycans is mediated by the step-wiseaddition of monosaccharides by a variety of ... efficiently convertedFITC–PTTT*PLK into the fully glycosylated form.Fig. 2. Representative profiles of MALDI-TOF MS of FITC–PTTTPLK peptide glycosylated by recombinant pp-GalNAc-T4 and separated by...
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Báo cáo Y học: Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle docx

Báo cáo Y học: Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle docx

... EcR and USP LBD are capable of dimerization in the absence of a bipartite EcRE, and thatthis protein protein interaction is dramatically enhancedby the presence of ecdysteroids.MATERIALS AND ... greatly enhanced upon adminis-tration of active ecdysteroids in a dose-dependent manner.This was shown in vivo by a yeast two-hybrid system and in vitro by a modified electromobility shift assay. ... expressed in yeast was functional and bound radioactively labelled ecdysteroid specifically.Ligand binding was greatly enhanced by the presence of aUSP ligand binding domain. Therefore, ecdysteroids...
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