Báo cáo y học: "Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells" doc

... pulmonary arteries [17,18].Activation of SOCs in pulmonary artery myocytes isregulated by PKG and PKAThe guanyl ate cyclase-cyclic GMP-protein kinase G sig-naling pathway plays a pivotal role in ... activated by protein kinase C in vascularmyocytes. J Physiol 2008, 586:2463-2476.9. Ng LC, Gurney AM: Store-operated channels mediate Ca2+influx andcontraction in rat pulmonary artery. Circ ... phospholipase A2; Ins(1,4,5)P3: inositol 1,4,5-triphosphate; PASMC: pulmonary artery smooth muscle cell; PKA: proteinkinase A; PKC: protein kinase C; PKG: protein kinase G; PMA: phorbol 12-myristate...

Tài liệu Báo cáo Y học: Toxicity of substrate-bound amyloid peptides on vascular smooth muscle cells is enhanced by homocysteine docx

... Patients with hyperhom-ocysteinemia have homocysteine levels in the 0.1–0.25 mMrange. In these studies, homocysteine was found to elicit adose-dependent increase in toxicity in VSMC. In thepresence ... onplastic alone, indicating that cell–substrate adhesion may beimportant in maintaining cell viability. Ab also caused anincrease in the number of apoptotic cells. This increase in apoptosis was ... toxicity was enhanced. In thepresence of homocysteine, Ab1–40 caused a 40% increase in toxicity over that with homocysteine alone, whileAb1–42 caused a further 50% increase in toxicity (Fig....

Báo cáo Y học: Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N1,N11-diethylnorspermine pdf

... N1,N11-diethylnorspermine (DENSPM) which induces a rapiddepletion o f all polyamines by downregulating the activityof the biosynthetic e nzymes and upregulating the activity ofthe catabolic enzyme ... etabolicpathway, the induction of SSAT results in the acetylation ofspermine and spermidine, which are subsequently oxidizedby polyamine oxidase to form spermidine and putrescine,respectively. In addition, ... polyamine a naloguesare presently undergoing Phase I and Phase II clinicalevaluations in the US. In L56Br-C1 cells, DENSPM treatment induced anincrease in SSAT activity, which resulted in...

Báo cáo y học: "Erythropoietic Protoporphyria Masquerading as Angioedema in a 4-Year-Old Female" docx

... predominance.3EPP is caused bya deficiency of ferrochelatase, the final enzyme in heme synthesis,which leads to an accumula-tion of protoporphyrin in various tissues, includ-ing the skin ... edema and erythema of the extrem-ities and hepatomegaly. Laboratory evaluation included elevated liver transaminases and plasma pro-toporphyrin, with normal urine porphyrins. Liver biopsy confirmed ... common presenting symptomamong allergy practices. Angioedema is caused byincreased vascular permeability in the subcuta-neous tissue of the skin and respiratory and gas-trointestinal tracts.1Acute...

Báo cáo y học: " Psychoeducation and the family burden in schizophrenia: a randomized controlled trial" docx

... to sustain their caring role. In the comprehensive Cochrane review of family interven-tions for schizophrenia that was updated in 2006, therewas no study of family psychoeducational interventionfrom ... maximum interaction with thepatient or who was directly involved with the patient wasincluded in the study. Mostly these were parents, spouses,siblings or any other significant relative. Family ... further investigation. Subcategories include:financial burden, effects on family routine, effects on fam-ily leisure, effects on family interaction, effects on physicalhealth of family members...

Báo cáo y học: "Expression of inflammatory host genes in Chlamydia trachomatis-infected human monocytes" docx

... B-cell-attracting chemokine; IL, interleukin; IP, interferon inducible protein; MCP, monocyte chemotactic protein; MIG, monokine induced by gamma-interferon; MIP, macrophage inflammatory protein; SCYA, ... immunoglobulin G; IL = interleukin; LIF = leukemia inhibitory factor; LPS = lipopolysaccharide; MCP-1 = monocyte chemotactic protein-1; MIP = macrophage inflammatory protein; MOI = multiplicity of infection; ... IA, Quayle AJ, Visintin A, Ingalls RR: Local-ization of TLR2 and MyD88 to Chlamydia trachomatis inclu-sions. Evidence for signaling by intracellular TLR2 duringinfection with an obligate intracellular...

Báo cáo y học: " High recombination rates and hotspots in a Plasmodium falciparum genetic cross" docx

... parental genotype callsA quick scan of the genotype inheritance revealed manydouble crossovers within small DNA segments that werelikely genotype calling errors in the progeny, particularlywhen ... reduced recombination [5,6]. Many factors can influ-ence estimates of RR (or more precisely outcrossingrate), including the intensity of transmission by mosqui-toes, diversity o f local parasite ... errors in geno-type calls were corrected using the procedures described in Materials and methods, leading to 3,184 high-qualitymSFPs (Table 1). Interestingly, there were approximatelytwiceasmanyuniqueprobesdistinguishingthe3D7parasite...

Báo cáo y học: "Proteome analysis of bronchoalveolar lavage in Pulmonary Langerhans cell histiocytosis" pptx

... biospy? Respiratory Medicine 2010;104:S81eS85. 2. Sundar KM, Gosselin MV, Chung HL, Cahill BC. Pulmonary Langerhans Cell Histiocytosis: Emerging Concepts in Pathobiology, Radiology, and Clinical ... ribosylation factor-like protein 3 and annexin A3 (ANXA3)), proteins involved in ion transport (such as serotransferrin (TRFE) and hemoglobin subunit beta) and several inflammatory proteins (including ... phosphorylase, pyruvate kinase isozymes, fibrinogen gamma chain, alpha 1B glycoprotein and actin cytoplasmic 1 were identified. BAL proteome analysis of PLCH patients also revealed several proteolytic...

Báo cáo y học: "Hemangioma related to Maffucci syndrome in a man: a case report" docx

... related to Maffucci syndrome in aman: a case reportTakeshi KondoAbstractIntroduction: Maffucci syndrome is a rare clinical entity (app roximately 200 cases have been reported in themedical literature) ... Maffucci syndrome, focusing on the pathologic nature ofthe submitted tissue, is reported.IntroductionMaffucci syndrome is a rare clinical entity (approxi-mately 200 cases have b een reported in ... Maffucci syndrome. His available clinicalinformation, however, was limited. One of the heman-giomas was removed and examined pathologically.Macroscopically, the lesion showed a serpentin e appear-ance...

Báo cáo y học: "Gender differences and inflammation: an in vitro model of blood cells stimulation in prepubescent children" pptx

... the cytokines are used, allow-ing high sensitivity. Specificity of the assay has been con-trolled by the manufacturer by excluding cross reactivitytowards 25 other cytokines, including growth ... Gender influences clinical presentations and markers in inflammatory diseases. In many chronic conditions, frequency of complications is greater in females, suggesting that continuous inflammatory ... differences in the cytokine responsesthat could explain gender differences in the inflammatoryprofile. Higher levels of cytokines in males could beexplained by differences in the complexe relationhipbetween...

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