... regulatory systems in inflammatory diseases of humans, including BD. We are interested in heme oxygenase(HO) -1, because accumulating evidence suggests that HO -1 protects the host in a variety of pathologic ... oxygenase -1 deficiency.J Clin Invest 19 99, 10 3 :12 9 -13 5.24. Kirino Y, Takeno M, Iwasaki M, Ueda A, Ohno S, Shirai A, KanamoriH, Tanaka K, Ishigatsubo Y: Increased serum HO -1 in hemo-phagocytic syndrome ... expression of HO -1 was identified in synovial tissues of patients with RA, in theabsence of elevated serum HO -1 levels [24,25]. Further anal-ysis using RA synovial cell lines suggests that HO -1 plays...