Báo cáo y học: "Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells" potx
Báo cáo y học: "Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells" potx
... resulting in decreased matrix production, particularly proteoglycan synthesis, and anincrease in degradation of IVD matrix by locally produced matrix metalloproteinases (MMPs) and ADAMTS (a disintegrin and ... Interleukin-1 receptorantagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human interverte-bral disc: an in situ zymographic and gene therapy study.Arthritis ... 2Assessment of immunopositive staining for CDMP 1 and 2 in human intervertebral discsAssessment of immunopositive staining for CDMP 1 and 2 in human intervertebral discs. Percentage of cells with...
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Báo cáo Y học: Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo potx
... results of themorphometric analysis indicated induction of mitochondrialbiogenesis by ectopic UCP1 in the unilocular adipocytes.The stimulatory effect of UCP1 on mitochondrial content and biogenesis ... expression in adipocytes. It may be also speculated that the effect of adrenergic system on mitochondrial biogenesis represents acompensation for decreased ef®ciency of energy conversion in adipocytes ... increasedexpression of the genes controlling oxidative capacity(COX), as well as that of UCP2, and depression of genesengaged in fatty acid synthesis. The molecular mechanism for the induction in mitochon...
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báo cáo hóa học:" Expression of Bone Morphogenetic Protein-2 in the Chondrogenic and Ossifying Sites of Calcific Tendinopathy and Traumatic Tendon Injury Rat Models" doc
... augmentation of bone and bone-ten-don junction regeneration [3,4]. Because of the role of BMP-2 in bone formation, it is commonly found in bone and is generally absent in tendon. We hypothesized ... and Kai Ming Chan1,2Address: 1Department of Orthopaedics and Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, PR China and 2The Hong Kong Jockey ... BMP-binding proteins such asNoggin and Chordin as well as intracellularly by Smad6,tob and Smurf1 [2]. Information on the expression of these osteogenic factors and BMP antagonists, in additionto...
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Báo cáo y học: "Suppression of bone morphogenetic protein inhibitors promotes osteogenic differentiation: therapeutic implications" doc
... differentiationby increasing BMP-2 bioavailability. Future characterization of all the inhibitors and technological advances in suppressingtheir expression (including gene therapy, small interferingRNA ... problem of inadequate bone healing. In addition, high concentrations - at high cost - of single growthfactors with a range of questionable carriers is the currentparadigm for bone induction in the ... authors demonstrated successful knockdown of chordinexpression by small-interfering RNA transfection of human MSCs cultured in an osteogenic medium, and they con-cluded that chordin suppression allows...
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Báo cáo y học: " Preparation of RGD-modified Long Circulating Liposome Loading Matrine, and its in vitro Anti-cancer Effects"
... permeability and retention (EPR) mechanism (7). However, the use of conventional vesicles cannot fully overcome their binding with serum components and uptake by mononuclear phagocyte system (MPS). ... following re-dissolution after freeze-drying, was separated by mini-gel columns of Sephadex-G50 prepared in advance. In brief, incubation mixtures of 200μL containing unloaded matrine and RGD-M-LCL ... observed that high concentrations of RGD-LCL alone induced cytotoxicity, but that the complex alone had minimal toxicity at lower concen-trations, indicating that most of the activity is attri-butable...
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Báo cáo y học: "Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis" ppt
... proteases in RA: MMP1 and MMP3 are secreted on stimulation by inflammatorycytokines; they degrade key components of cartilage and bone matrix [6]. MMP1 expression occurs in cells of theinvading front ... determination of theconcentration of MMP1 and MMP3 and stored at –80°C(see below).GenotypingMMP1 and MMP3 promoter polymorphisms weredetermined by single-strand conformation polymorphismanalysis. ... downstream of the inflammatorycascade. MMP1 and MMP3 are involved in processes of tissue remodelling, including wound healing and angio-genesis, but also in cancer invasion and inflammatory jointdestruction...
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Báo cáo y học: "Expression of bioactive bone morphogenetic proteins in the subacromial bursa of patients with chronic degeneration of the rotator cuff" pptx
... induction of AP [9].Figure 2Hematoxylin-eosin staining (a) and indirect immunofluorescence for collagen types I (b) and II (c) in comparable areasHematoxylin-eosin staining (a) and indirect immunofluorescence ... tendon, and always close to vessel orduct structures and the acinar elements in the acromial portion(Figure 4).Expression of mRNA for bone morphogenetic protein, matrix proteins, and cytokinesFigures ... that chronic degeneration of therotator cuff is associated with inflammation-related induction of bone morphogenetic protein (BMP) activity in the joint. Thedeposition and activation of significant...
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Báo cáo y học: "Expression of Human Globular Adiponectin-Glucagon-Like Peptide-1 Analog Fusion Protein and Its Assay of Glucose-Lowering Effect In Vivo"
... present in inclusion body. In order to recover its function, the fusion protein in inclusion body was refolded in urea gradient refolding buffer. And then, the refolded protein was incubated ... treat type 2 daibetes by improving both insulin resistance and insulin secretion deficiency. However, we only ob-served the glucose-lowering effect of the whole fusion protein in this study. ... SDS-PAGE analysis showed that most of the fusion protein was in inclusion body (Fig. 2A). Western blot using mouse anti-His-tag monoclonal antibody also proved that majority of fusion protein was...
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Báo cáo y học: "Expression of hMSH2 protein of the human DNA mismatch repair system in oral lichen planus"
... omission of the primary or the secondary antibody or primary incubation in the presence of non-immunized rabbit serum instead of the primary antibody. Cell quantification and Statistical analysis ... applying 0.01% diaminobenzidine tetrahydrochloride and 0.03% H2O2. Sections were counterstained with Meyer’s haematoxylin and mounted in PermountTM. Negative controls consisted of omission ... classified among these chronic disorders. Many inflammatory factors known to be related with cancer initiation, progression, and invasion are also expressed by OLP-related chronic inflammatory infiltrate,...
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Báo cáo Y học: Expression of the V-ATPase proteolipid subunit of Acetabularia acetabulum in a VMA3-deficient strain of Saccharomyces cerevisiae and study of its complementation pdf
... coding for the subunits A and B of V-ATPase. The intracellular localization of these isoforms and the combination of the isoforms is yet to be determined.We are now trying to express fusion proteins ... cDNA and genomic cloning of sugar beet V-typeH1-ATPase subunit A and c isoforms: evidence for coordinateexpression during plant development and cooridinate induction in response to high salinity. ... –Bertani/ampicillin medium and the plasmid DNA was purified over a Qiagen-Tip100column.Conversion of TAA to CAA and preparation of recombinants in yeast expression vector In the case of AACEVAPD1, 3 and...
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