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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt

Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx

Báo cáo Y học: Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways docx

... 2002 Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1 Implications for apoptosis signaling pathways Takenori Takizawa 1 , Chizuru Tatematsu 1 and Yoshinobu ... S.,Kirchhoff,S.,Hauser,H.,Decker,T.&Koromilas,A.E. (19 97)Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways. EMBO J. 16 , 12 91 13 04. 613 2 ... signal-regulating kinase 1 (ASK1)by the adapter protein Daxx. Science 2 81, 18 60 18 63.20. Takizawa, T., Ohashi, K. & Nakanishi, Y. (19 96) Possibleinvolvement of double-stranded RNA-activated protein kinase (PKR)...
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Báo cáo y học: "Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis." pdf

... uniquelyexpressed genes.Selection of hypervariable (HV) genes To have an opportunity to evaluate inhomogeneity in gene expression variability, it is necessary to normalize this vari-ability to ... articleNovel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritisJames N Jarvis*1, Igor Dozmorov*2, Kaiyu Jiang1, Mark Barton Frank2, Peter Szodoray3, ... means of identifying the genes involved in a given pathophysiol-ogy. Our analysis identified key regulators of innate immu-nity and inflammation including the proinflammatorymediators formyl...
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Báo cáo y học: "p53 tumor suppressor gene mutations in fibroblast-like synoviocytes from erosion synovium and non-erosion synovium in rheumatoid arthritis" ppsx

... ondestruction.Conclusions Mutations of the p53 tumor suppressor gene were present in synoviocytes isolated from both erosion and non -erosion sites in longstanding RA. Clusters of mutations can occur in RA synovium, but the ... non -erosion sites wereexamined. Ten erosion FLS lines and nine non -erosion FLSlines were established from nine patients with RA (two ero-sion lines and one non -erosion line were examined in ... consideredsignificant.Resultsp53 mutations in erosion FLS and non -erosion FLSTo determine whether invasive synovium in RA has anincreased number of mutations, p53 cDNA subclones from FLS derived from erosion sites and non-erosion...
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Báo cáo y học: "Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia" docx

... 'sympathetically maintained pain'[5].Naturally occurring sympathetic neurotransmitters are cate-cholamines known as norepinephrine, epinephrine, and dopamine. All three substances act within the ... frequentCOMT gene haplotypes strongly associated with sensitivity toexperimental pain and induction of a more defective COMTenzyme. Healthy females with the 'high pain sensitivity haplo-type' ... associated with greater sensitivity to pain. Allthe individuals in the study were female. Fifty-seven Mexican patients and 78 Spanish patients were compared with theirrespective healthy control...
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Báo cáo y học: "Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis" pot

... antigen-specific T-cell repertoire isspontaneously enriched in synovial fluid. The specific T-cell repertoire in the periphery was modulated by therapy and decreased with the remission of the disease. ... prominentrole in joint inflammation. The T-cell mediated self-reactivityCDR3: third complementarity-determining region; CFSE: carboxyfluorescein diacetate succinimidyl ester; DAS: Disease Activity Score; ... 1.33% and 2.9% in the total lymphocyte population and within the CD4+ subset, respectively. (Panel b) Treg cells are efficiently removed (0.05% and 1.1% in the total lymphocyte population and within...
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Báo cáo y học: " Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment" doc

... concentrations of norepinephrine in thetissue (nerve fiber loss) [1,5]. Minor stress and probably alsoReview Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatmentMaurizio ... tolerance and efficacy in autoimmune rheumatic diseases[16]. Insights into neurohormonal effects ofmelatonin in autoimmunity MLT is an important neurohormone mainly synthesized by thepineal gland ... hormones of the adrenal(cortisol) and gonadal glands (sex hormones), neurohormonessuch as melatonin, and more recently the vitamin D endocrinesystem. Estrogens, melatonin and chronic stress (inducingdecreased...
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Báo cáo y học: "Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration" ppt

... gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 2006,87:17-28.7. Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of ... AJ: Interleukin-1 receptorantagonist delivered directly and by gene therapy inhibitsmatrix degradation in the intact degenerate human interverte-bral disc: an in situ zymographic and gene therapy ... degenerate NP cells by the action of TNF-α.DiscussionThis study investigates the effect of the pro-inflammatorycytokines IL-1β and TNF-α on catabolic gene expression in normal and degenerate IVD cells....
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Báo cáo y học: " Co-receptor tropism prediction among 1045 Indian HIV-1 subtype C sequences: Therapeutic implications for India" potx

... PCR was carried out with a forwardprimer, FP1: 5-CACCGGCTTAGGCATCTCCTATGG-CAGGAAGAA-3 and reverse primer RP1: 5-TAACCCTTCCAGGTACCCCCTTTTCTTTTA-3. Thenested PCR was carried out with the forward ... 5′-tgtaaaacgacggccagtCTGTTAAATGGCAGTC-TAGC and reverse primer, RP2: 5′-caggaaacagctatgacc-CACTTCTCCAATTGTCCCTCA. Primers FP2 and RP2contain the M13 universal primer sequence (lower case),which was ... studying co-receptor tropism prediction among African subtype C strains reported100% concordance of C- PS SM with phenotypic assayin detecting CXCR4 [12]. Our data supports the predo-minance...
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Báo cáo y học: " Continuing or adding IL-2 in patients treated with antiretroviral therapy (ACTG Protocol A5051, a rollover trial of ACTG Protocol A3" pps

... this article as: Bosch et al.: Continuing or adding IL-2 in patients treated with antiretroviral therapy (ACTG Protocol A5 051, a rollover trial of ACTG Protocol A3 28). AIDS Research and Therapy ... therapy (ACTG Protocol A5 051, a rollover trial of ACTG Protocol A3 28)Ronald J Bosch1*, Richard B Pollard2, Alan Landay3, Evgenia Aga1, Lawrence Fox4, Ronald Mitsuyasu5AbstractBackground: ... et al. AIDS Research and Therapy 2010, 7:30http://www.aidsrestherapy.com/content/7/1/30Page 5 of 5 RESEA R C H Open Access Continuing or adding IL-2 in patients treated with antiretroviral therapy...
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Báo cáo y học: " Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, I: analysis of cases" pdf

... work is properly cited.Research article Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, I: analysis of casesHolland ... Stickelmeyer M, Sorsaburu S, Watson SB, Mitchell MI: Post-injection delirium/sedation syndrome in patients with schizophrenia treated with olanzapine long-acting injection, II: investigations of ... timing of signs and symptoms of post-injection delirium/sedation syndrome (PDSS) occurring with olanzapine long-acting injectionClinical Symptoms of PDSS Events Grouped Presented InitiallyN (%)Occurred...
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Báo cáo y học: "Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes" pdf

... properly cited.Research articleTranscriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypesBen ... Transcriptional profiling of bovine inter-vertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes Arthritis Research & Therapy 2010, ... characterise the bovine NP and IVD cell pheno-types. Although SNAP25 and TNMD may be good markers of bovine NP cells and IVD cells, respectively, given theirlack of expression in AC cells, their...
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Báo cáo y học: "Heat shock protein 70 expression, keratin phosphorylation and Mallory body formation in hepatocytes from griseofulvin-intoxicated mice" pptx

... wasDistribution of keratin IFs and HSP70i in hepatocytes from control and GF-fed C3H miceFigure 2Distribution of keratin IFs and HSP70i in hepatocytes from control and GF-fed C3H mice. A, C, E keratin IFs; ... of keratin IFs and K8 pS436 in hepatocytes from control and GF-fed C3H miceFigure 4Distribution of keratin IFs and K8 pS436 in hepatocytes from control and GF-fed C3H mice. A, C, E, G keratin ... during incubationstep with secondary antibody. For heat shock proteinsstaining, liver sections were incubated with anti-HSP 70idiluted in TBS containing 10% BSA for 45 min at 37°C,washed in...
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Báo cáo y học: "A consensus prognostic gene expression classifier for ER positive breast cancer" pptx

... genesGene ontology analysis results for the top 200 prognostic genes.Click here for fileAdditional data file 8Gene ontology analysis results for the top 200 prognostic genesGene ontology analysis ... optimal classifier performedindependently of the ER gene expression level (data notshown) in ER+ tumors. The overlap of the 52 -gene classifier with either van't Veer's or Wang's prognostic ... results for the top 200 prognostic genes.Click here for fileAdditional data file 9Gene ontology analysis results for the top 200 prognostic genesGene ontology analysis results for the top 200 prognostic...
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Báo cáo y học: " Male reproductive development: gene expression profiling of maize anther and pollen ontogeny" ppt

... Genome Biology 2008, 9:R181Open Access2008Maet al.Volume 9, Issue 12, Article R181Research Male reproductive development: gene expression profiling of maize anther and pollen ontogenyJiong MaÔ, ... meiosis and later pollen dispersal. Synchronous development of many anthers pertassel and within each anther facilitates dissection of carefully staged maize anthers fortranscriptome profiling. Results: ... Global gene expression profiles of 7 stages representing 29 days of anther developmentare analyzed using a 44 K oligonucleotide array querying approximately 80% of maize protein-coding genes....
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