Báo cáo y học: "Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes" doc
Báo cáo y học: "Peroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytes" doc
... 2Research articlePeroxisome proliferator-activated receptor γ1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1β in articular chondrocytesHassan Afif1, ... proliferator-acti-vated receptor γ inhibits interleukin-1β- induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1. J Biol Chem2004, ... expression of PPARγ in OA cartilage may, at least in part, be involved in increased expression of inflammatory and catabolic genes,promoting articular inflammation and cartilage degradation. In addition,...
- 11
- 558
- 0
Báo cáo y học: "κ Exposure to receptor-activator of NFκB ligand renders preγ osteoclasts resistant to IFN-γ by inducing terminal differentiation'''' pdf
... anti-osteoclastactivity is mediated by inducing terminal differentiationaway from the osteoclast lineage, while IL-4 directly inter-feres with RANKL signaling during osteoclastogenesis.Collectively, these findings ... osteoclastogenesis in vitro, it is also known that this cytokine is produced in particularsettings of inflammatory bone loss, such as infection and psoriatic arthritis. Because of the different kinetics ... 15 and 60 min, and then protein extracts were analyzed by immunoblotting asdescribed in Materials and methods. Multiple signals were achieved by stripping and reprobing the same blot. TRAF6 expression...
- 11
- 280
- 0
Báo cáo y học: " Toll-like receptor homolog RP105 modulates the antigen-presenting cell function and regulates the development of collagen-induced arthritis" pot
... defense, they also play importantroles in inflammatory diseases [4]. Rheumatoid arthritis (RA) is a chronic autoimmune and inflammatory disease characterized by synovial inflammation and destruction ... cell puritywas greater than 90% by flow cytometry, and the contaminat-ing cells were mainly non-T non-B cells. Foxp3 staining wasperformed to compare the purity and its expression in recov-ered ... arthritis in rats. ArthritisRheum 2004, 50:297-304.26. Yarilina A, DiCarlo E, Ivashkiv LB: Suppression of the effectorphase of inflammatory arthritis by double-stranded RNA is mediated by type...
- 11
- 502
- 0
Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... 14distress syndrome within 30 days following inclusion.The secondary endpoint was overall survival within 30days following study inclusion. Outcomes were assessedduring hospital stay at days ... cryptate emission.Competing interestsNo commercial sponsor had any involvement in design and conduct of thisstudy, namely, the collection, management, analysis, and interpretation of thedata; and ... determine mortalityrisks and rely mostly on age as the main driver of mortal-ity [4]. However, calculation of the PSI in daily practice is time consuming which limits its dissemination and implementation...
- 14
- 497
- 0
Báo cáo y học: "Rasburicase represents a new tool for hyperuricemia in tumor lysis syndrome and in gout Lisa Cammalleri and Mariano Malaguarnera"
... DNA and RNA synthesis, and inosine that will be degraded into hypoxanthine and xanthine and finally into uric acid. Hypoxanthine and guanine may enter in a sal-vage pathway, using hypoxanthine-guanine ... pharmacodynamics It is an enzyme whose action consists in catalyz-ing the oxidation of uric acid into allantoin, rapidly excreted by the kidneys. Allantoin is poorly toxic and easy cleared, also in ... analogous of hypoxanthine, inhibitor of xanthine oxi-dase, the last enzyme involved in uric acid synthesis pathway. It catalyzes the conversion of hypoxanyhine into xanthine and this latter into uric...
- 11
- 715
- 0
Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... substrate binding pocket. Few examples exist in whichthe ratio between hydrolysis and aminolysis was changed by changing the catalytic nucleophile. By replacing the active-site serine in subtilisin ... Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, the NetherlandsPenicillin acylase of Escherichia coli catalyses the hydrolysis and synthesis of ... methyl ester or the amide asacyl donor.It appeared that 6-APA and 7-ADCA were able toefficiently deacylate the phenylglycyl- and p-hydroxyphe-nylglycyl-enzyme of bF24A, as indicated by, respectively,...
- 8
- 561
- 0
Báo cáo khoa học: The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto Functional and structural insights through disulfide structure analysis docx
... characterization by mass spectrometry and N-terminalsequencing. These studies showed that Cys115 forms adisulfide bond with Cys133, Cys128 with Cys149, and Cys131 with Cys140. Protein database searching and molecular ... 2 is in patterning and morphogenesis in earlyembryonic development [35,36]. Although JAGGED 2 is not fucosylated as Cripto is [2,12], the function of NOTCHligand is reportedly regulated by ... toresidues 74–169 completely alkylated with IAM, withheterogeneity in glycosylation. Masses corresponding toprotein containing 2-(N-ethylsuccinimidyl)-cysteine (NES-Cys) residues were not detected....
- 9
- 428
- 0
Báo cáo y học: "Magnetic resonance imaging changes of sacroiliac joints in patients with recent-onset inflammatory back pain: inter-reader reliability and prevalence of abnormalities" potx
... sclerosis, ankylosis), by twoobservers independently. Agreement between the two readerswas analysed by concordance and discordance rates and by kappa statistics.Inflammation was present in 32 ... pain present (%) 96aHLA-B27 present (%) 46History of inflammatory bowel disease present (%) 15History of uveitis present (%) 15History of psoriasis present (%) 24Family history of ankylosing ... be ascertained in future, by following thepatients longitudinally and obtaining more data, which willoccur in this cohort. The development and choice of an appro-priate scoring system for...
- 6
- 400
- 0
Báo cáo y học: " Functional inhibition of NF-κB signal transduction in αvβ3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IκB gene" ppsx
... (TNF)-α activa-tion, leading to diminished expression of intercellular adhesion mole-cule-1 protein as determined by flow cytometryDnIκB expression in human umbilical vein endothelial cells (HUVECs) ... tumor necrosis factor (TNF)-α stimulation in human umbilical vein endothelial cells (HUVECs) as determined by flow cytometry. Minus and plus signs and denotes resting, non-infected, and TNF-α ... initiated by the high affinity bind-ing of the carboxy-terminal 'knob' part of the fiber protein tocoxsacki-adenovirus receptor (CAR), thereby limiting its infec-tion specificity to CAR-positive...
- 10
- 418
- 0
Báo cáo y học: "Contribution of KIR3DL1/3DS1 to ankylosing spondylitis in human leukocyte antigen-B27 Caucasian populations." pps
... KIR3DS1 and theinhibitory 3DL1 are located in the intracytoplasmic tail. Theinhibitory receptor has a long tail containing immunoreceptortyrosine inhibitory motifs, whereas the activating receptor ... of HLA-B27 by KIR orILT could influence their immunomodulatory function and mayimply a role in inflammatory disease.Binding of the KIR3DL1 receptor to the Bw4 family of MHCclass I receptors ... ankylosing spondylitis; HC = heavy chain; HLA = human leukocyte antigen; HWE = Hardy-Weinberg equilibrium; ILT = immunoglobulin-like lymphocyte T receptors; KIR = killer cell immunoglobulin-like...
- 5
- 408
- 0
Từ khóa: Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtchuong 1 tong quan quan tri rui roGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vật