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Báo cáo y học: " Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2" pot

Báo cáo y học:

Báo cáo y học: " Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein and exhibit decreased activity of the lipoprotein-associated phospholipase A2" pot

... Weinvestigated the plasma levels of oxLDL and Lp-PLA2 activity aswell as the autoantibody titers against mildly oxLDL in patients with early rheumatoid arthritis (ERA). The long-term effects of immunointervention ... 1 of 8(page number not for citation purposes)Vol 9 No 1Research article Patients with early rheumatoid arthritis exhibit elevated autoantibody titers against mildly oxidized low-density lipoprotein ... AD: The low-density lipoprotein (LDL)-associated PAF-acetylhydrolase activity and the extent of LDL oxidation are important determi-nants of the autoantibody titers against oxidized LDL inpatients...
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Báo cáo y học: "Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood" pps

... assay to evaluate the level of EBV genome in the peripheral blood of SLE patients. We could detect and quantify EBV DNA in almostall of the patients with SLE and the control individuals. The SLE ... control.MarkerdH2OAG876Namalwa1234567891011EBNA-2EBNA-3BEBNA-3C300bp200bp300bp200bp100bp300bp200bpType 2 (186bp)Type 1 (168bp)Type 2 (149bp)Type 1 (125bp)Type 2 (246bp)Type 1 (153bp) Arthritis Research & Therapy Vol 6 No 4 Moon et al.R302 patients with rheumatoid arthritis and systemic ... do not directly reflect EBV status within the body. Clarification of the precise status of EBV infection inSLE patients would help to improve our understanding of the role played by EBV in this...
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Báo cáo y học: "B lymphocytopenia in rheumatoid arthritis is associated with the DRB1 shared epitope and increased acute phase response" docx

... otherautoantibodies [2,6,23,24]. The goal of the present studywas therefore the analysis of frequencies and distributions of B-lymphocyte subpopulations, and the comparison of patients positive and negative for ... description of CD19low and CD19high patients The CD19lowgroup of patients and the CD19highgroup of patients were compared in both the retrospective studycohort and the prospective study cohort with ... study of RA patients with recent-onsetdisease, TRUCOUNT®technology in a whole blood assaywas applied to determine absolute numbers of both B lym-phocytes and T lymphocytes. At the time of...
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Báo cáo y học: "Bone erosions in rheumatoid arthritis can be repaired through reduction in disease activity with conventional disease-modifying antirheumatic drugs." pot

... each patient, and the Ethics Committee of the Yokohama City Medical Centerapproved the study protocol.ResultsRA patients with paired sequential radiographs of both hands and wrists exhibiting ... JE: Epidemiology and genetics of rheuma-toid arthritis. Arthritis Res 2002:S265-272.2. Brower AC: Use of the radiograph to measure the course of rheumatoid arthritis. The gold standard versus ... according to the 1987American College of Rheumatology criteria for RA. Fromamong RA patients seen in the rheumatology clinic by two of the authors (HI and SO) at Yokohama City University MedicalCenter...
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Báo cáo y học: " Forefoot pathology in rheumatoid arthritis identified with ultrasound may not localise to areas of highest pressure: cohort observations at baseline and twelve months" ppt

... and location of MTP joint synovial hypertrophy and forefoot bursal hypertrophy (Table 7). This suggests that the pattern of presence of MTP joint synovial hypertrophy and forefoot bursal hypertrophy ... excluded from the final analyses. A gender matched healthy comparison group was recruited from the students and staff of the University of Southampton and assessed at the start of the study at baseline ... identify the presence of soft tissue pathology within the forefoot using US and patterns of foot-shoe interface pressures in a large cohort of patients with RA at two time points. Primarily we...
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Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx

... sensitivity mightalso be due to the choice of a different cut-off of positivityfor the aPL autoantibody test and to the different clinicalcharacteristics of the patients analyzed. Thus, the ACL ... [30-32]. Most of the studies reporting a highfrequency of aPL autoantibodies were conducted with non-standard tests; furthermore, the titers of most of the posi-tive sera were very low. The difference ... Prospectiveevaluation of the frequency and clinical significance of antineutrophil cytoplasmic and anticardiolipin antibodies incommunity cases of patients with rheumatoid arthritis. Rheu-matology (Oxford)...
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Báo cáo y học: "Homing chemokines in rheumatoid arthritis" doc

... the synovial lining layer and organize into lymphocyte aggregates with germinalcentres (GCs) [19–21]. These ectopic lymphoid struc-tures share many features with secondary lymphoid tissue and ... analysis of chemokine receptor expression in RA synovial T lympho-cytes. The marked expression of the chemokine recep-tors CXCR3, CXCR6 and CCR5 on memory CD4+Tlymphocytes, which represent the ... granulo-cytes, and MCP-1, RANTES and MIP-1α, which actprimarily on monocytes and lymphocytes, are involved in the selective recruitment and activation of these cells.Recent studies have focused on the...
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Báo cáo y học: "Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis" pps

... receptors) are elevated and correlate with the severity of the disease [107-112] regard-less of etiology of CHF. In patients with no overt CHF orhistory of ischemic heart disease, those with the highestserum ... in the myocardium leading to congestive heart failure. At present, however, the direct effects of inflammatory cytokines (and rheumatoid arthritis therapies) on the myocardia of rheumatoid arthritis ... Chronic hypertension promotes the development of CHF by a variety of mechanisms,including the induction of maladaptive myocardial remodeling and atherosclerosis. Reports of the prevalence of hypertension...
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Báo cáo y học: "Immune complexes from rheumatoid arthritis synovial fluid induce FcγRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-α by peripheral blood mononuclear cells" potx

... purposes)ResultsComparison of sera and synovial fluids from rheumatoid arthritis patients with healthy control seraIn the first study we compared paired sera and SF from 15 RA patients with sera from 15 healthy control ... this way we aim to test the hypothesisthat RF-associated induction of proinflammatory cytokines byjoint ICs is a stable quality over space and time in individual patients with RA.In the present ... collected the patient data and samples, and helped to draft the manuscript. MM helped with the laboratory work, and read and approved the final manuscript. JR participated in the design of the study,...
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Báo cáo y học: "Epigenetic modifications in rheumatoid arthritis" pptx

... activity of LINE-1 was associated with genomichypomethylation in RASFs. In accordance, very recent datastrongly support the hypothesis that genomichypomethylation might play a key role in the pathogenesis ... diversity of possible interactions amplifies the complexity of the regula-tion of protein-coding genes. The degree of complementary of the seed sequence with the target mRNA determines the Available ... residues at the N-terminus of the histones [15]. Such hyperacetylation isassociated with the opening of the chromatin and thus with an enhanced rate of gene transcription. On the other hand,targeted...
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