... Interest-ingly, the gradual loss of sialic acid O-acetylation, partic-ularly oligo-O-acetylated sialic acids, has been identified asan early alteration accompanying the adenoma-carcinomasequence in ... acid;Neu2,7an5Ac, 5-N-acetyl-2,7-anhydro-neuraminic acid; Neu5Gc,5-N-glycolyl-neuraminic acid; OAE, sialate-O-acetylesterase;OAE-C, cytosolic sialate-O-acetylesterase; OAE-L, lysosomal sialate-O-acetylesterase; ... assumed that a single dominant geneencoding an OAT (oat) regulates sialate O-acetylation. Forexample, approximately 9% of apparently normal Europe-ans are believed to be homozygous (oat–/oat–)...