Báo cáo khoa học: "Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia" docx

... OncologyOpen AccessResearchEpstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in MalaysiaHui Shien See1, ... characteristics and histological type with 30-bp deletion and XhoI-loss studiesin NPC tissue and plasma samplesNumber of 30-bp deletion in LMP1 (%) Number of Loss of Xho I site (%) Co-existence of 30-bp ... EBV LMP1 30-bp deletion and XhoI-loss variants were found to be predominant in undif-ferentiated carcinomas (Type III) compared to keratiniz-ing squamous cell carcinoma (Type I). This suggests...

Tài liệu Báo cáo khoa học: Identiﬁcation of a novel matrix protein contained in a protein aggregate associated with collagen in ﬁsh otoliths pdf

... determine the calcium-binding domain ofthe protein. (A) Schematic drawing of the recombinant proteins. SixGST-fused recombinant proteins containing the three distinctivedomains of tandem repeat 1 ... recombinantproteins, rOMM-64-I, III, IV and V, which include theGlu-rich domain, were found to have calcium-bindingactivity. rOMM-64-II and -C and GST were stainedred using ‘Stains-all’ and ... aggregatecontains OMM-64 and otolin-1 within the otolithFig. 5. OMM-64 is contained in the HMW aggregate in the otolithmatrix and is excised from the aggregate by deglycosylation usingTFMS or heparitinase...

Tài liệu Báo cáo khoa học: Fatty acid synthesis Role of active site histidines and lysine in Cys-His-His-type b-ketoacyl-acyl carrier protein synthases ppt

... binding of ACP tothe docking site followed by a conformational change in ACP proposed to inject the acyl chain into the sub-strate-binding pocket [32]. If a similar mechanism is involved in ... wild -type, H298E and H298Q proteins in 30 minassays. The amount of labeled substrate present at the start of the reactions is shown in the ﬁrst lane. C is a standard consisting of malo-nyl-ACP and ... synthesisRole of active site histidines and lysine in Cys-His-His -type b-ketoacyl-acyl carrier protein synthasesPenny von Wettstein-Knowles1, Johan G. Olsen2, Kirsten A. McGuire1 and Anette...

Báo cáo khoa học: Fully active QAE isoform confers thermal hysteresis activity on a defective SP isoform of type III antifreeze protein docx

... no signiﬁcant protein–proteininteraction between the two isoforms, which is in goodagreement with the proposed independent ice-bindingmodel of AFP [35,36]. Kristiansen and Zachariassen[4] ... preliminary X-ray structure of nfeAFP6 (data notshown) obtained was indistinguishable from that ofordinary type III AFP (i.e. HPLC12) [14,18]. There is a 41% sequence difference between nfeAFP6 and AFP8, ... activities obtained for nfeAFP8 and the 1 : 1 mixture of nfeAFP6 and nfeAFP8 wereindistinguishable (Fig. 4B). The level of depression ofTburstfor nfeAFP6 was also indistinguishable fromthat...

Báo cáo khoa học: "The relationship among acute-phase response proteins, cytokines and hormones in cachectic patients with colon cancer" doc

... catabolism is mainly mediated by the effects of certain cytokines, suchas tumor necrosis factor-a (TNF-a), interleukin-1β(IL-1β ), and interleukin-6 (IL-6) [4,8], the mechanisms associated with ... [23].Ghrelin participates directly in hypothalamic regula-tion of nutrition, it causes weight gain by reducing foodutilization, increasing food intake, and inhibiting leptin-induced feeding reduction ... circulating IL-6 and midkine, independently of the patients weight status, and with Il-1, Il-8 and VEGF in cachectic cancer patients.TNF-a, IL-1 and IL-6 are key cytokines involved in can-cer-related...

Báo cáo khoa học: Sendai virus N-terminal fusion peptide consists of two similar repeats, both of which contribute to membrane fusion ppt

... property correlated well with the infectivity of in uenza virus containing single amino-acid mutations in the fusionpeptide segment of hemagglutinin [16]. Here we observed aninverse correlation ... & Nieva, J.L.(2000) Membrane interface-interacting sequences within theectodomain of the human immunodeﬁciency virus type 1 envelopeglycoprotein: putative role during viral fusion. J. Virol. ... peptides in measles virus- induced membrane fusion: emerging similarity with other Paramyxoviruses. Biochemistry 40, 1340–1349.24. Ghosh,J.K.,Peisajovich,S.G.&Shai,Y.(2000)Sendaivirusinternal...

Tài liệu Báo cáo khoa học: The Mycobacterium tuberculosis membrane protein Rv2560 ) biochemical and functional studies pdf

... anti-TBvaccine candidate.Rv2560 is a proline- and glycine-rich transmembraneprotein, and may thus be classiﬁed as a simplesequence protein (SSP). This type of sequence is fre-quent in organisms having ... buffer for 15 min at 80 °C. After 1 h ofblocking in Tris-buffered saline (NaCl ⁄ Tris) (0.05 m Tris in isotonic saline, pH 7.6) containing 0.05% BSA, the gridswere incubated in either 1 : 10 ... U937 and A549 cells (in this case), their binding dissociationconstants, their critical binding residues and their role in cell invasion inhibition, with the speciﬁc purpose ofemploying them as probable...

Tài liệu Báo cáo khoa học: Identiﬁcation of membrane-bound serine proteinase matriptase as processing enzyme of insulin-like growth factor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25) doc

... follows: aprotinin, leu-peptin, pepstatin A, AEBSF and proteinase inhibitor mixturethat contains AEBSF, aprotinin, bestatin, E-64, leupeptin and pepstatin A from Wako Pure Chemical Industries(Osaka, ... of insulin-like growthfactor binding protein-related protein-1 (IGFBP-rP1 ⁄ mac25) in the M12 prostate cancer cell line alterstumor growth by a delay in G1 and cyclin A associated apoptosis. ... of membrane- bound serine proteinasematriptase as processing enzyme of insulin-like growthfactor binding protein-related protein-1 (IGFBP-rP1/angiomodulin/mac25)Sanjida Ahmed1,2, Xinlian Jin1,...

Tài liệu Báo cáo khoa học: "Learning the Latent Semantics of a Concept from its Deﬁnition" pptx

... similarity with wmfvec. In In-degree, two senses are connected if their words arewithin a local window. We use the optimal windowsize of 6 tested in (Sinha and Mihalcea, 2007; Guo and Diab, ... the dominant topic based on the ob-served words in a definition (f inancial topic in bank#n#1 and stock#n#1) without further dis-cernibility. In this case, many senses will share thesame latent ... long as they are in the same topic/domain.To solve the sparsity issue we use missing wordsas negative evidence of latent semantics, as in (Guo and Diab, 2012). We define missing words of a sensedefinition...

Tài liệu Báo cáo khoa học: "Semi-supervised latent variable models for sentence-level sentiment analysis" pdf

... coarse-grained supervision is naturallyabundant in the form of online review ratings. Thiscoarse-grained supervision is, of course, less infor-mative compared to fine-grained supervision, how-ever, ... which is natu-rally abundant but less informative, with fine-grainedsupervision, which is scarce but more informative.To this end, we introduced two simple, yet effective,methods of combining ... demonstrate how combiningcoarse-grained and fine-grained supervision bene-fits sentence-level sentiment analysis – an importanttask in the field of opinion classification and retrieval(Pang and Lee, 2008)....

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