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Báo cáo y học: "DAS28 best reflects the physician''''''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx

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Báo cáo y học: "DAS28 best reflects the physician''''s clinical judgment of response to infliximab therapy in rheumatoid arthritis patients: validation of the DAS28 score in patients under infliximab treatment" potx

... givea dose increase of infliximab could happen only at one timepoint. This difference in study design and therapy may explainwhy in the present study the AUC of DAS28 is smaller than in other studies ... coefficients of this discriminant function were quite similar to the coefficients of the DAS28, indicating the robustness of the scores andcoefficients of the DAS28 score. In another, final analysis, ... online http:/ /arthritis- research.com/content/7/5/R1063R1063Vol 7 No 5Research article DAS28 best reflects the physician's clinical judgment of response to infliximab therapy in rheumatoid...
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Báo cáo y học: "Gene expression profiling in the synovium identifies a predictive signature of absence of response to adalimumab therapy in rheumatoid arthritis" doc

... with response to therapy in baseline PBMC samples. They confirmed the asso-ciation of 20 of these transcripts with response to therapy in an additional set of 20 patients [27]. It is striking, ... associ-ated with poor clinical response to therapy, thereby providingclinicians with potential tools to identify these patients prior to initiation of adalimumab treatment. Finally, we demonstratedthat ... significantly overexpressed at baseline in poor responders are induced by several cytokines in FLSs,thereby suggesting a role for these cytokines in the resistance to TNF blockade in RA.ANOVA: analysis...
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Báo cáo y học: "Ultrasonography, magnetic resonance imaging, radiography, and clinical assessment of inflammatory and destructive changes in fingers and toes of patients with psoriatic arthritis" pot

... toolincreasingly used by clinicians, including rheumatologists, but the US data on small joints in PsA are very limited [8,9]; in particular, the validation of the findings is minimal. The aim of the ... purposes)Ratingen scoring system [11] by an experienced musculoskel-etal radiologist (AV) blinded to clinical and other imagingfindings. Clinical examinationAll 25 persons underwent clinical examination ... study was to assess US for the detection of inflam-matory and destructive changes in finger and toe joints, ten-dons, and entheses in patients with PsA by comparison withMRI, x-ray, and clinical...
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Báo cáo y học: " Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells" docx

... assay, flow cytometry analysis, and immunoblot analysis. Blockade of TLR3 signaling was achievedusing TLR3 neutralizing antibody, small interference RNA, and 2-aminopurine (2-AP), an inhibitor of ... Ganglioneuroblastoma; (IRF3):Interferon regulatory factor 3; (NB): Neuroblastoma; (PKR): Double-strandedRNA-dependent protein kinase; (poly(I:C): Polyinosinic-p olycytidylic acid);(TLR): Toll-like receptor.AcknowledgementsThis ... level determined the sensitivity of NB cells to poly(I:C)-induced celldeath. Our study may open a new avenue of therapeuticindication for TLR3 agonists as an adjuvant therapy in intractable...
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Báo cáo y học: " Preliminary data concerning the reliability and psychometric properties of the Greek translation of the 20-item Subjective Well-Being Under Neuroleptic Treatment Scale (SWN-20)" pdf

... in order to assess the well-being of patients receiving antipsychoticmedication independent of the improvement in their psychotic symptoms. The current studyreports on the reliability and the ... designed the study and participated in the analysis of the data, interpretation and writing of the manuscript MS,KM, EP, SM, IC, KA, AC and SD participated in the gather-ing of the data, interpretation ... treated eitherwith FGAs or SGAs showed that both quality of life andsymptom severity improved over the study period, regard-less of the antipsychotic taken, indicating that the type of antipsychotic...
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Báo cáo y học: "Mechanical ventilation and the total artificial heart: optimal ventilator trigger to avoid post-operative autocycling - a case series and literature review" pdf

... 10 patients developed autocycling of the ventilator, but autocycling ceased immediately in all of these patients when their ventilator settings werechanged from a flow trigger of 2 L/minute to ... ventilator setting. Mechanicalventilator PEEP maintenance maintains pressure at the expense of altered flow, ultimately leading to autocycling in the case of a flow trigger. Given the frequency of ... ventilator, the baseline continuous expiratoryflow is set at 1.5 L/min greater than the set flow trigger (2L/min in our case), resulting in a continuous expiratoryflow of 3.5 L/min. The patients& apos;...
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Báo cáo y học: "Weight loss, leukopenia and thrombocytopenia associated with sustained virologic response to Hepatitis C treatmen"

... determined by evaluating the median results of the groups and deciding among the investigators clinical importance. From the data, clinically relevant cut-offs determined by the investi-gators ... at the beginning and at the end of therapy. The Knodell scoring sys-tem for liver biopsy (obtained at baseline) result was used as the indicator of histologic activity. Statistical analysis. ... 070.54. During the period of study, 78 pa-tients started on therapy. Twenty four patients were not included in the study analysis due to fail to com-plete treatment and evaluation. Of these, 13...
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Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

... thisunderstanding is gained, H-tunneling can then be used asa tool for (a) increasing the catalytic efficiency of enzymes in the biotechnology industry (by enhancing the coupling of dynamics to the ... by tunneling in quinoprotein andflavoprotein enzymes that catalyse the oxidation of anumber of amine substrates, and computational studies of enzymic H-tunneling in these enzymes.QUINOPROTEIN ... H-tunneling is driven by the thermally induced dynamics of the enzyme. In some of thoseenzymes that break stable C–H bonds the reaction proceedspurely by quantum tunneling, without the need to partiallyascend...
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Báo cáo khoa học: "First observations on the root morphology and symbioses of 21 major tree species in the primary tropical rain forest of French Guyana" pps

... ecto-mycorrhizal symbioses seem to be less fre-quent in Venezuela and the Guyanas than in other tropical rain forests, in spite of the factthat the soil fertility is ... in French Guyana, no local factoris responsible for the rarity of ectomycor-rhizas. Introduced pines and eucalyps in nearby plantations were massively ecto-mycorrhizal. Our ... probably playsa major role in the seedling mortality, andthus in the regeneration dynamics of thesespecies. Indeed, D guianensis is one of the species with the highest...
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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt

... levels of RAGE expression, which is induced by AGE,can contribute to the inflammatory cycle by the induction of proinflammatory cytokines, via the nuclear factor-κBpathway [21]. No studies have yet ... is linked to the inflammatory response rather than to hyperglycemia. The latter is key in the AGE associated with diabetes [3]. We did notmeasure hemoglobin A1c in the present study, but in aprevious ... USA).Results The clinical characteristics of the early synovitis patients are shown in Table 1. A total of 105 patients met the American College of Rheumatology criteria for RA. Of the patients meeting...
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