Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
Báo cáo y học: " Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients" pdf
... meet the variable demands imposed by the intermittent course of RA. Evidence from animal models convincingly supports the application of gene therapy in RA, and the feasibility of gene therapy was ... synovial lininglayer in both arthritis models. An alternative approach for suicide gene therapy is to inhibit cell proliferation. The cellcycle is controlled by the kinase activity of cyclin/cyclin-dependent ... around the fact that the rheumatoid factors in RApatients may form immune complexes with the immunoglobulin domain of the tgAAC94 fusion protein,thereby inactivating the therapeutic protein in the...
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Báo cáo y học: " Epitope spreading in animal models: array of hope in rheumatoid arthritis and multiple sclerosis" pot
... todealing with the range of autoantigens that might bepathogenic in RA and MS by array technology. They used253 antigens for their synovial array and 406 for their myelinarray. This, of course, ... furthercontrol not examined was the testing of the CII immunisedmice on the myelin array or vice versa. A controversial finding in this study was the demonstration of citrulline specificity for the antibodies ... citrullinated proteins in both inflamedsynovium and brain tissue. Other interpretations, however,include the possibility that antibodies to citrullinated proteinsarise as a result of polyclonal...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... ideal for human germline gene therapy. A major problem is the relatively low rate of transgene integration: in mice, the overall efficiency of transgenesis (taking into account embryo loss in ... purpose of this paper is to consider the potential for applying the available genetic modification (GM) technologies to the goal of achieving human germline gene therapy. If germline gene therapy ... solely upon scientific issues related to human germline gene therapy. 2. Criteria for Assessing Applicability to Human Germline Gene Therapy An ideal gene transfer system in the context of human...
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Báo cáo y học: "Gene therapy of the rheumatic diseases: 1998 to 2008" ppt
... met byresponsible gene therapy protocols using safe vectors. Twoclinical trials exploring the use of gene therapy in OA are under way and another is in the pipeline. If successful, theycould ... arthritis gene therapy in the refereedliterature. The data are based on a PubMed search using ‘arthritis gene therapy as the search term. The first paper on arthritis gene therapy waspublished in ... equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene. Gene Ther 2002, 9:12-20.84. Cucchiarini M, Madry H: Gene therapy for cartilage defects. JGene...
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Báo cáo y học: " In vivo imaging approaches in animal models of rheumatoid arthritis" pot
... and gener-ally reduced the signs of inflammation. The groundwork for further studies on the dynamics of lymphocyte interactions in the synovium has thus been established.Most of the work in intravital ... leukocyteand lymphocyte migration in the parenchyma of tissues canbe followed in vivo by imaging in thin tissues like the mesen-teries or by fluorescence intravital microscopy, but there hasbeen very ... imaging of leukocytes hasfocused on the interaction of lymphocytes with endothelialcells, and has only minimally addressed the issues of whatleukocytes do after they extravasate. While leukocytes...
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Báo cáo y học: "Infliximab therapy in rheumatoid arthritis and ankylosing spondylitis-induced specific antinuclear and antiphospholipid autoantibodies without autoimmune clinical manifestations: a two-year prospective study" potx
... complement-dependent cellular cytotoxicity of the cells expressing the cytokine [37]. Furthermore, infliximab has been shown toincrease the number of apoptotic T lymphocytes in the lam-ina propria [38] and ... and clinical statuses are pre-sented in Table 1. Patients were followed clinically by the same physician during this period at regular intervals and in particular when they were receiving infliximab ... of the posi-tive sera were very low. The difference in sensitivity mightalso be due to the choice of a different cut-off of positivity for the aPL autoantibody test and to the different clinicalcharacteristics...
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Báo cáo y học: "Gene profiling in white blood cells predicts infliximab responsiveness in rheumatoid arthritis" potx
... PTPN12, are found among lists of genes that are directlyregulated by the TNFα/NFκB pathway, whether in RA [41] or in another context [42,43]. Therefore, it is likely that most of our transcripts are ... and detailed in Table 4. The identity of the corre-sponding microarray cDNA probes was verified by sequenc-ing. Finally, we performed an unsupervised hierarchicalclustering of the 13 patients ... were identified byonly one IMAGE clone without knowledge of the intron/exonstructure and, therefore, they were not retained. Moreover,among the 29 remaining transcripts, 9 of them failed to...
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Báo cáo y học: "Biological therapy in early arthritis – overtreatment or the way to go" pptx
... study, dependingon the way in which productivity is valued, the costs of infliximab could be compensated for by savings in productivity [48]. Another study reviewing costs in earlyinflammatory ... diseaseprocesses and the prevention of development of furtherinflammation [9-11]. DMARDs are currently the first line of therapy in early inflammatory disease; however, with the availability of more effective ... blockade therapy Identifying patients who benefit the most from TNF-blocking therapy is a reasonable strategy for optimising the use of these drugs. This includes determining factors for poorprognosis in patients...
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Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
... whether they currently smoked and the number of cigarettes smoked per day. From these reports, we calculatedpack years of smoking (product of years of smoking and packs of cigarettes per day).Other ... smokers wereasked for the number of cigarettes typically smoked per dayand former smokers reported the age at which they stoppedsmoking and the number of cigarettes smoked per day beforequitting. ... from ours, in that they did notfind a significant interaction between the presence of the PTPN22 polymorphism and smoking in determining RA risk.Their gene- smoking interaction analyses used...
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Báo cáo y học: "Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG" pdf
... (LIPC) is a lipolytic enzyme synthesized in hepatocytes playing a major role in HDL metabolism. Ittakes part in hydrolysis of triacylglycerides and phosphol-ipids of HDL2 into antiatherogenic, ... we constructed a risk profile. Carriers of the risk profile weredefined as having one of the following polymorphisms:hetero- or homozygous for the variants of eNOS 4ab, the ApoE allele combination 2/4 ... purposes)Knowledge of gene polymorphisms in the era of genomicsand their influence on outcome in cardiac surgery is rap-idly growing. However, most studies investigated the acute effects of polymorphisms...
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