... with atypical antipsychotic drugs. Although understanding of the pathophysiology of akathisiaremains limited, it seems that a complex interplay of several neurotransmitter systems might play ... the clinical profile of akathisia, it seemsthat a complex interplay of several neurotransmitter sys-tems (for example, dopamine, acetylcholine, norepi-nephrine, serotonin, g-aminobutyric acid ... akathisia, they showonly a moderate efficacy, and a substantial proportion of patients fail to respond to treatment. In contrast, under-standing of the pathophysiology of akathisia rema inslimited....