... (p0), the peptide (0.1–2 lm) was injectedinto the subphase, and the increment in surface pressure of the LPS film upon intercalation of the peptide dissolved in the subphase was monitored for the ... of microbes present in the inoculum. Afterwards, toexamine the killing activity of Esc(1–18) against E. coli and to determine whether this process was affected by the ionic strength of the incubation ... damage and loss of cellular integrity, with a partial discharge of the cellular contents, within 20 min (Fig. 11). Theseresults correlate with the killing kinetics of the peptide, and show that the...