... exist at all) [10]. Hemoglobin, CO, arterial oxygensaturation, and arterial oxygen tension are the shared variablesused in calculating both DO2and VO2. To avoid mathematicalcoupling, it has ... many patients in thetreatment arms of these trials did not achieve the targetvalues. Rather than inadequate treatment, it is more likely thatthe patients who did not achieve target values had ... fact that control patients whogenerated high CI and DO2despite conservative treatment,also had lower mortality, supports the latter explanation.Supporters of high CO also argue that many...