... mutation thatintroduces an extra four amino acids [45], a single amino aciddeletion [20], and an inframe interstitial deletion of nine aminoacids, all in the extracellular domain [16]. Remarkably, ... conjunctivitis, headaches, chestpain, myalgia, arthralgia, and less commonly arthritis andother inflammatory manifestations including fasciitis, myo-carditis, sacroiliitis, pharyngitis, and stomatitis ... E, Gadina M, Karenko L, Petters-son T, et al.: Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of domi-nantly inherited autoinflammatory syndromes....