... disor-der of unknown aetiology, characterized by intimal lining layerhyperplasia, infiltration of the sublining area by macrophages,T and B lymphocytes, plasma cells and other inflammatorycells as ... in synovial fluidmacrophages. Arthritis Res 2002, 4:R9.54. Harigai M, Hara M, Kawamoto M, Kawaguchi Y, Sugiura T, TanakaM, Nakagawa M, Ichida H, Takagi K, Higami-Ohsako S, et al.:Amplification ... the acute phase of AIA. These dataimply that activation of the STAT-1 pathway plays an importantrole in our Th1 cell-mediated arthritis model.Th1 cell function is already an essential pathogenic...