... FEBS Production of biologically active forms of recombinant hepcidin, the iron-regulatory hormone Bruno Gagliardo1, Audrey Faye2,3, Maryse Jaouen1, Jean-Christophe Deschemin2,3, FrancáoisCanonne-Hergaux4, ... peptide hormone that acts as the central regulator of body iron metabolism. Hepcidin is synthesized under the form of a precursor, prohepcidin, which is processed to produce the biologically active ... by the four-disulfide bridges [10,16]. Other studies havereported the purification of human recombinant hepci-din in the form of fusion proteins [25–28] and, untilvery recently [29], none of the...