... form of BuChE, as indicated. In each panel, the solidcircles indicate the measured kcatvalues, the solid squares indicate the measured bkcatvalues, and the lines are the result of fitting the ... form of BuChE, as indicated. In each panel, the solid circlesindicate the measured kcatvalues, the solid squares indicate the measured bkcatvalues, and the lines are the result of fitting the ... carboxylate (aspartate in chymotrypsin, glutamate in cholinesterases) of the cata-lytic triad. Compression of the His-Asp/Glu diad causes the basicity of the histidine to increase, so that it...