... Barak D, Kronman C, Ordentlich A, Ariel N,Bromberg A, Marcus D, Lazar A, Velan B &Shafferman A (1994) Acetylcholinesterase peripheralanionic site degeneracy conferred by amino acidarrays ... obtained byassuming that mutations did not affect binding ofsubstrate at the peripheral site (Kp), the rate constantfor deacetylation (k3) and the acceleration of deacety-lation (a) . Any ... substrate hydrolysisbecause the traffic can pass via an alternative route, presumably theenlarged back channel.AbbreviationsCAS, acylation site; DmAChE, Drosophila acetylcholinesterase; PAS,...