Chapter 080 Cancer Cell Biology and Angiogenesis (Part 9) ppt
Chapter 080. Cancer Cell Biology and Angiogenesis (Part 9) ppt
... cutaneous T cell lymphoma (e.g., vorinostat) and some solid tumors. HDAC inhibitors may target cancer cells via a number of mechanisms including upregulation of death receptors (DR4/5, FAS, and their ... (DR4/5, FAS, and their ligands) and p21Cip1/Waf1, as well as inhibition of cell cycle checkpoints. The pattern of gene transcription is aberrant in all human cancers, and in many cases, epigenetic ... activity of CDK4/cyclin D and rendering pRB nonfunctional. In sporadic forms of renal, breast, and colon cancer, the von Hippel–Lindau (VHL), breast cancer 1 (BRCA1), and serine/threonine kinase...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3) ppt
... before the clinical utility of this approach can be fully realized. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 3) Figure 80-1 ... other stimuli, and predisposes cells to chromosome instability. This genomic instability greatly increases the probability that p53 null cells will acquire additional mutations and become malignant. ... transcription factor activity and tumor-suppressor functions, and also result in high intracellular levels of p53 protein. Inactivation of the p53 pathway compromises cell cycle arrest, attenuates...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 12) ppt
... -C, and -D are produced by tumor cells and stromal cells in response to hypoxia or oncogenic signals, and induce production of new blood vessels and lymphatic channels through which tumor cells ... factor beta (TGF-β) and the hepatocyte growth factor (HGF)/c-Met pathways, as well as changes in the expression of adhesion molecules that mediate cell- cell and cell- extracellular matrix interactions. ... Osteoblasts and other stromal cells express RANK ligand, as both a membrane-bound and soluble cytokine. Osteoprotegerin (OPG), a soluble receptor for RANK ligand produced by stromal cells, acts...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 1) pps
... synthesis and mitosis and in response to environmental mutagens; these repair pathways are often abnormal in cancer cells. When a normal cell has sustained too much damage to repair, the cell activates ... damage to the organ. These cell death pathways are also commonly altered in cancer cells, leading to the survival of damaged cells that would normally die. Cancer cells often exist under conditions ... breast, and pancreatic cancers. Table 80-1 Phenotypic Characteristics of Malignant Cells Deregulated cell proliferation: Loss of negative regulators (suppressor oncogenes, i.e., Rb, p53), and...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 2) ppsx
... whether a cell will enter S-phase. The complex of CDK4 or CDK6 with D type cyclins forms a G1-specific kinase whose activity is regulated by growth factors, nutrients, and cell- cell and cell- matrix ... targeted therapy of cancer. Therapeutic Approaches to Cell Cycle Abnormalities in Cancer The mechanism of cell division is substantially the same in all dividing cells and has been conserved ... nonmalignant cells, have become possible with advances in the understanding of oncogene and tumor-suppressor pathways. This chapter describes the convergence of scientific, pharmacologic, and medical...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) ppsx
... melanoma, prostate, lung, breast, and colon cancer cells in vitro. Clinical trials of telomerase vaccines are underway. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 4) Telomerase DNA ... epithelium, and germ cells) that require extensive cell division to maintain tissue homeostasis. More than 90% of human cancers express high levels of telomerase that prevent telomere exhaustion and ... (e.g., Myc, AP-1, and serum response factor) and the cell cycle machinery (CDKs and cyclins). Inhibitors of many of these pathways have been developed for the treatment of human cancers. Examples...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 5) pps
... Breast cancer Binds HER2 on tumor cell surface and induces receptor internalization. Cetuximab (Erbitux) EGFR Colon cancer, squamous cell carcinoma of the head and neck Binds extracellular ... Possible activity against BRAF in melanoma, colon cancer, and others. Erlotinib (Tarceva) EGFR Non-small cell lung cancer; pancreatic cancer Competitive inhibitor of the ATP binding ... of EGFR and blocks binding of EGF and TGF-α; induces receptor internalization. Potentiates the efficacy chemotherapy and radiotherapy. Panitumomab (Vectibix) EGFR Colon cancer Like...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 6) potx
... of tumor cells and induces internalization of the receptor, thereby reducing the level of surface expression. This leads to inhibition of cell cycle progression and renders cancer cells more ... breast cancer patients. The PDGFR and its ligand, platelet-derived growth factor (PDGF), are overexpressed in many glioblastomas and in subsets of melanoma, ovarian, pancreatic, gastric, lung, and ... human cancer, and provide a mechanism to identify subsets of patients likely to respond to the targeted therapy. The wild-type EGFR is expressed by many other human cancers, and in colon cancer...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 7) docx
... the cancer cell, without harming normal cells (which maintain wild-type function for gene A). High-throughput screens can now be performed using isogenic cell line pairs in which one cell ... transition and passage through the cell cycle. Inhibition of one pathway (such as pathway A by a targeted inhibitor) has no significant effect due to redundancy provided by pathways B and C. In cancer ... cancer cells, oncogenic mutations lead over time to dependency on the activated pathway, with loss of significant input from pathways B and C. The dependency or addiction of the cancer cell to...
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Chapter 080. Cancer Cell Biology and Angiogenesis (Part 8) pdf
... that may include growth arrest, differentiation, or apoptosis. Chapter 080. Cancer Cell Biology and Angiogenesis (Part 8) PI3K is a heterodimeric lipid kinase that catalyses the conversion ... of Myc, β-catenin, cyclin D1, and cyclin E, and blocking upregulation of p27Kip1 and Bim (an apoptosis-inducing protein). Furthermore, the growth of cancer cells requires the activation of ... gene expression in cancer cells. Tumor-suppressor genes are often epigenetically silenced in cancer cells. In the upper dephosphorylating PIP3, is mutated in many human cancers, leading to...
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