... significant weight loss (Chap. 71). Causes of Weight Loss The list of possible causes of weight loss is extensive (Table 41-1). In the elderly, the most common causes of weight loss are depression, ... present with weight loss and weakness, with few other manifestations of thyrotoxicosis. New-onset diabetes mellitus is often accompanied by weight loss, reflecting glucosuria and loss of the ... the mouth and teeth Age-related factors Physiologic changes Significance of Weight Loss Unintentional weight loss, especially in the elderly, is relatively common and is associated with increased...