... Mode of action of the microbial metabolite GE23077, a novel potent and selective inhibitor of bacterial RNA polymeraseEdoardo Sarubbià, Federica Monti*, Emiliana Corti, Anna Miele and Enrico ... (a2bb¢x,withacombined molecular m ass of % 400 kDa) and is capable of elongation and termination. The initiation-competent Ôholo ÕRNAP is compo sed of the core enzyme and of an additionalsubunit, r, which confers ... of intensive research, RNAP is currently the subject of renewed interest and excitement, owing to recentpublication o f the crystal structures o f t he core [4] and holo[5,6] enzymes, and of...