báo cáo hóa học:" Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer" ppt
Báo cáo khoa học: The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence doc
... The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence Yunpeng Feng*, Xiuli Wang*, Liang Xu, Hong Pan, Shan Zhu, Qian Liang, ... extraction and real-time quantitative PCRTotal cellular RNA was extracted from the 293T cellsaccording to the Promega Total RNA Isolation System man-ual. RNA was resuspended in RNase-free water and ... HDAC3 was recruited to the p16 pro-moter through ZBP-89. On the basis of these data, wediscuss the possible mechanisms of the functionalinteractions among ZBP-89, HDAC3 and HDAC4 in p16 transcriptional...
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Báo cáo khoa học: Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging pdf
... charac-teristics resemble those of the natural aging process in humans and other animals. As the inner ear tissue isunacquirable during life in humans, and the genetic and environmental background ... increased mutation load in the inner ear. In our study, increases in TFAM expression and dele-tion mutation load were demonstrated in the inner ear of d-Gal-treated rats. The replication of mtDNA is ... reported that the capacity to repair oxidative DNA damage in various brain regionsduring aging was altered in an age-dependent manner, and increased mtDNA oxidative damage might con-tribute to the...
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Báo cáo khoa học: A transcription factor of lipid synthesis, sterol regulatory element-binding protein (SREBP)-1a causes G1 cell-cycle arrest after accumulation of cyclin-dependent kinase (cdk) inhibitors pdf
... primer, 5¢-CAAAACCGAACAAAAGCGAAACGCCA-3¢,5¢ primer, 5¢-CAACCCATCCAAATCCAGACAAAAT-3¢. All constructs were confirmed bysequencing. The p21 (Waf1 ⁄ Cip1) promoter luciferase con-struct has been described ... ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1, 193–199.17 Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N,Imaki H, Hatakeyama S, Nakayama K & NakayamaKI (2003) Degradation ... Nakakuki M, Matsuzaka T,Nakagawa Y, Yamamoto T, Sato R, Takahashi A, Sone H, Yahagi N et al. (2005) Lipid synthetic tran-scription factor SREBP- 1a activates p21WAF1 ⁄ CIP1, a universal cyclin-dependent...
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Báo cáo khoa học: Sp3 transcription factor is crucial for transcriptional activation of the human NOX4 gene doc
... essential for transcriptional activation of the human NOX4 promoterFigure 1 shows the alignment of the 5¢-flanking and5¢-noncoding sequences of the human, rat and mouse NOX4 genes. Compared with the ... similaritybetween the rat and mouse sequences, the similarity of the human sequence was relatively low. Therefore, weisolated the promoter region of the human NOX4 gene and examined its transcriptional ... IgG. Gene silencing of Sp3 attenuated the promoteractivity of the NOX4 gene To examine whether Sp1 and Sp3 are actually involvedin transcription of the NOX4 gene, an anti-Sp1 oranti -Sp3 short...
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Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
... reproduc-tion in any medium, provided the original work is properly cited.Research Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy ... an increase of Epidermal Growth factor Receptor (EGFR) Gene Copy Number (GCN). Aim of this study was to assess the role of EGFR-GCN in advanced colorectal cancer (CRC) patients receiving chemotherapy ... between patients with increased EGFR-GCNTable 1: FISH DataPatterns FISH Patients %Increased EGFR gene copy number in >50% of cells56 /101 56EGFR gene copy number <40% of cells28 /101 28EGFR...
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báo cáo hóa học: " Neuronal oxidative damage and dendritic degeneration following activation of CD14-dependent innate immune response in vivo" doc
... alsoactivate CD14-dependent innate immune response in macrophages. While none of these data point to CD14 or innate immune response as etiological in neurodegenera-tive disorders, these findings from in ... A2,each of which are potent activators of a large family of Gprotein-coupled receptors [5]. The combination of theseinitial and secondary signaling cascades produces a robust innate immune response. ... element of secondary signaling pathways, alsocompletely blocks ICV LPS-induced neuronal oxidative damage. Finally, mice lacking prostaglandin E2 receptorsubtype 2 (EP2), one of four prostaglandin...
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báo cáo hóa học: " Platelet-activating factor enhancement of calcium influx and interleukin-6 expression, but not production, in human microglia" pptx
... 1 of 8(page number not for citation purposes)Journal of NeuroinflammationOpen AccessResearch Platelet-activating factor enhancement of calcium influx and interleukin-6 expression, but not ... In brief, human embryonicbrain tissues were dissected into small blocks, incubated in phosphate-buffered saline (PBS) containing 0.25%trypsin and 40 µg/ml DNase and then dissociated intosingle ... mediated[Ca2+]i influx in mediating actions of the inflammatorystimulus PAF to induce IL-6 in human microglia.Materials and methodsPreparation of cellsThe procedures for the isolation of human microglia...
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báo cáo hóa học: " Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes" pdf
... transmigration of monocytes and macrophages across the BBB to the sites of axonal injury in the brain [33,37]. Both in vitro and in vivofindings suggest that hypoxia/ischemia-induced infiltra-tion of monocytes ... HIF-1-binding sites in the pro-moter regions of MCP-1 and MCP-5 genes. Hypoxia and CoCl2 up-regulate the expression of both HIF-1α and chemokines MCP-1 and MCP-5 in astrocytes. The levels of MCP-5 ... wedemonstrate the role of HIF-1α in hypoxia-induced up -regulation of inflammatory chemokines, human monocyte chemoattractant protein-1 (MCP-1/CCL2) and mouse MCP-5 (Ccl12), in human and mouse astrocytes,...
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báo cáo hóa học: " Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice" docx
... histopathology Hematoxylin and Eosin staining was performed. Double Immunostaining was used to detect astrocytes and T-cells. In brief, sections were washed in PBS, followed by rinsing in PBS-0.5% Triton ... findings point to IRF7 as a key signaling intermediate in modulation of autoimmune demyelinating disease, and open the possibility that innate signals may also be protective. Leukocyte infiltration ... differences in data obtained from intracellular cytokine staining and cytokine message measured in spinal cords could be attributed to the fact that IL17 message detected by PCR in IRF7-KO could originate...
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báo cáo hóa học: " Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway" doc
... contributing to 1 Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway Leonid Tarassishin*, Hyeon-Sook Suh, and Sunhee ... versions will be made available soon. Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathwayJournal of Neuroinflammation 2011, 8:187 doi:10.1186/1742-2094-8-187Leonid ... required PI3K/Akt. Conclusions: Our results show a novel anti-inflammatory role for the PI3K/Akt signaling pathway in microglia. They further suggest that IRF3 gene therapy could facilitate the microglial...
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báo cáo hóa học:" Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer" ppt
... al.: Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer. Journal of Ovarian Research ... 12RESEA R C H Open Access Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancerNuzhat ... 11 of 12pattern of Brn-3a(l) in primary tumors, ascites tumor cells and ovarian cancer cell lin es consistent with noveldistinct role of this factor in the progression and recur-rence of this...
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Báo cáo hóa học: " Research Article Appropriate Algorithms for EstimatingFrequency-Selective Rician Fading MIMO Channels and Channel Rice Factor: Substantial Benefits of Rician Model and Estimator Tradeoffs" ppt
... LS and SLS estimators isindependent of κ. The channel will be no fading or AWGNwhen κ→∞.6.5. Substantial Benefits of the Rician Fading MIMO Channels. In Tables 3 and 4, substantial benefits of ... 2010, Article ID 753637, 14 pagesdoi:10.1155/2010/753637 Research Article Appropriate Algorithms for Estimat i ngFrequency-Selective Rician Fading MIMO Channels and Channel Rice Factor: Substantial ... JLS/NRNT of the LS channel estimator versus SNR in the Rayleigh (κ= 0) and Rician (κ= 1, 10) fading channels. As it is expected,the performance of the LS estimator is independent of the fading model. ...
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báo cáo hóa học:" An endogenous factor enhances ferulic acid decarboxylation catalyzed by phenolic acid decarboxylase from Candida guilliermondii" potx
... designed from an internal LKNKHFQYTYDNGWKYEFHV) and P2 (a reverse primer designed from an internal AFSQGHWEHPEQAHGDKRED), and nested PCR was done with P1 and P3 (a reverse primer designed from an ... suggested that an endogenous amino thiol-like compound with a molecular weight greater than Mr 1,400 was responsible for the activation. Keywords: phenolic acid decarboxylase, ferulic acid decarboxylase, ... doi:10.1046/j.1432-1327.2001.02308.x. Huang HK, Tokashiki M, Maeno S, Onaga S, Taira T, Ito S (2011) Purification and properties of phenolic acid decarboxylase from Candida guilliermondii. J Ind Microbiol...
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Báo cáo hóa học: " A Technique for Dominant Path Delay Estimation in an OFDM System and Its Application to Frame " docx
... OFDM System and Its Application to Frame Synchronization in OFDM Mode of WMANCh. Nanda Kishore and V. U. ReddyHellosoft India Pvt Ltd., 8-2-703, Road no. 12, Banjara Hills, Hyderabad 500 034, IndiaReceived ... scheme for transmitting data at very high ratesover time dispersive radio channels. In an OFDM system, frame synchronization and frequency offset estimation are extremelyimportant for maintaining ... demonstrate its utility.ACKNOWLEDGMENTSCh. Nanda Kishore would like to thank S. Rama Rao, VicePresident and General Manager of Hellosoft India Pvt. Ltd. and Dr. Y. Yoganandam, Senior Technical...
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báo cáo khoa học: " The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in Arabidopsis" potx
... 11:19http://www.biomedcentral.com/1471-2229/11/19Page 8 of 10RESEARCH ARTICLE Open Access The transcription factor PHR1 plays a key role in the regulation of sulfate shoot-to-root flux upon phosphate starvation in ArabidopsisHatem ... Kataoka T, Watanabe-Takahashi A, Hayashi N, Ohnishi M, Mimura T,Buchner P, Hawkesford MJ, Yamaya T, Takahashi H: Vacuolar sulfate transporters are essential determinants controlling internal ... Takahashi H, Watanabe-Takahashi A, Smith FW, Blake-Kalff M,Hawkesford MJ, Saito K: The roles of three functional sulphatetransporters involved in uptake and translocation of sulphate in Arabidopsis...
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