... improved stability in vivo because the two chains in the diabody are connected to < /b> each othervia a linker [14,30]. In general, papain and pepsin have been used in the preparation of < /b> antibody fragments ... (1999) Bispecific anti-bodies in cancer therapy, from the laboratory to < /b> the clinic. J Immunother 22, 514–524.4 Segal DM, Weiner GJ & Weiner LM (1999) Bispecificantibodies in cancer therapy. ... distance between the two anti-gen-binding sites of < /b> the diabodies that is large enough to < /b> bring two cells together for recruitment of < /b> immunecells [1,2,28].Large-scale production of < /b> bi-specific diabodies...