... Age-related accumulation of damaged mitochondria and lipofuscin inclusions within postmitotic cells. Oxidative injury to mitochondrial DNA and proteins may disturb fission of some mitochondria, ... oxidative damage,resulting in decreasing energy production and increasinggeneration of reactive oxygen species. Damaged, enlarged and functionally disabled mitochondria gradually displacenormal ones, ... diseases, ionizing radiation, tumors, etc. [7,8].However, despite different etiology, the mechanisms of lysosomal pigment formation and its composition arebasically the same in aging and disease.In...