... concept and design: CA and OB. Acquisition of data: CA and OB. Analysis and interpretation of data: CA, OB, MMO, AMS, and BF. Drafting of the manuscript: CA and OB. Critical revision of the manuscript ... Nantes, UNAM, Nantes, France.Authors’ contributionsCA has full access to the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analyses. Study ... for inclusion in the meta-analyses [16,17,21].Asanexample,anegative study was excluded from the last meta -analysis because patients were in an un stable health state” although itwas not an initial...