... heterotetramericmetalloprotein composed with four globin chains; two of alpha chains (α1, α2, ζ, μ, and θ) and two of beta chains(β, δ, G-γ, A-γ, and ε). Each globin molecule binds oneheme molecule [10]. In humans ... adults to determine if changes in their abundance coincide with the developmental phenomenon of hemoglobin switching.Methods: Expression profiling of microRNA was performed using total RNA from ... 2 internal controls with 7 serial dilutionswas printed in house (Immunogenetics Laboratory,Department of Transfusion Medicine, Clinical Center,National Institutes of Health). Validation of...