... directlylinked to the aggregation of mutant proteins. Proteinaggregates, in the form of amyloid plaques, neurofibril-lary tangles, intracytoplasmic or intranuclear inclusions[1] lead to increased ... toxicity, using a model amyloidogenic protein, human stefin B. Stefin B is a member of the I25 family of cystatins (MEROPS classification), the cysteine pro-teinase inhibitors [12]. Its main pathology ... binding of the aggregated forms,albeit to a much smaller extent than that observed forsome proteins that bind specifically to membranes,such as the small membrane-binding domains involvedin...