... ±Figure 3 Examination of the role of the avb3 and avb5 integrins in mediating vitronectin induction of microglial activation. Wild-type,b3 integrin KO, b5 integrin KO and b3/b5 integrin DKO microglia ... b3integrinKO,b5integrinKOandb3/b5integrin DKO. In the first set of experiments, we exam-inedtheroleofav integrins in mediating microglialadhesion to vitronectin. In 30-minute adhesion assays,Welser-Alves et al. Journal of ... whetheravb8 is a functional vitronectin receptor in microglia,we examined the effect of function-blocking anti-b1integrin antibodies on microglial adhesion to vitronectin.Under these conditions,...