... anthracyclines, are positivelycharged and therefore bind to acidic groups in proteins and membranes. Thus, their movement into the cellcan be envisaged as a series of binding and releasingevents ... reported in the present study, and obtained in living cells, confirm the finding obtained in reconsti-tuted proteoliposomes [11,12] and isolated membranes[29,30] indicating that Pgp and a bacterial ... active uptake of TMRM into the mitochon-dria interferes with the second phase of TMA-DPHquenching (Fig. 2). Initially, there is significant inhibi-tion of the quenching in the respiring cells,...