... congenic TLR4 ) ⁄ )C.C3 -Tlr4 lps-dmice. In contrast to our results, theyshowed that bLF-stimulated IjB degradation wasrather enhanced in TLR4 ) ⁄ )macrophages, suggestingthat TLR4 is not ... pathway.TRIF-dependent NF-jB activation proceeds down-stream of TLR3 or TLR4 . However, TLR3 -triggeredsignaling is independent of MyD88, whereas TLR4 activates both MyD88-dependent and MyD88-indepen-dent ... 4 (TLR4 ), a unique TLR group member that triggersboth MyD88-depependent and MyD88-independent signalings. Impor-tantly, the carbohydrate chains from hLF are shown to be responsible for TLR4 ...