... manifestations of OA of the knee include pain in and around the joint, stiffness of the joint, crepitation on motion and limited joint mo -tion, among others [4]. Current recommendations for ... recruitment and manage-ment, and data collection. ARS and AM worked with subjects to obtain informed consent, conducted clini-cal evaluations, took samples and evaluated thera-peutic response of 5-Loxin® ... inves-tigators at baseline and on each follow-up visit (days 7, 30, 60 and 90). Questionnaire-based assessment of pain, stiffness and physical function were done using the Western Ontario and McMaster Universities...