... are used clinically, including epoetin alfa and epoetin beta.Epoetin alfa (marketed as Epogen®,Procrit®, Eprex®, and Erypo®) is available in most ofthe developed world, including the United ... decreases nonlinearly with increas-ing dose, resulting in a longer half-life of rHuEPO as the dose administered is increased(65). In multiple-dose studies of intravenous rHuEPO in healthy subjects, ... threefoldincreased serum half-life and increased in vivo potency, allowing for more flexiblemodes of administration, including extended dosing. Other rHuEPO moieties such asepoetin omega, are...