... studies, the intervention is imple-mented. The last stage of the evidence loop is the monitor-ing of patients or population groups and the reassessment of the value and necessity of continuing the ... they apply to the potential recipients of the preventive intervention [12]? The level of evidence indicates the validity of evalua-tive research and takes into account the design of the study, ... necessary to bringabout a change in the environment of the tooth and of the rest of the dentition so as to prevent further caries, includ-ing the development of new primary carious lesions [6].Thus,...