... contraction through the activatingmechanisms that involve the region spanning from the structural TnC-binding site to the inhibitory region of TnI. Together with the observationthat corresponding ... troponin com-plex but also for Ca2+-dependent activation.AbbreviationsTnC, troponin-C; TnI, troponin-I; TnT, troponin-T; IPTG, isopropyl-1-thio-b-D-galactopyranoside; PMSF, phenylmethylsulfonyl ... causes the exposure of a hydropho-bic patch on the surface of the N-domain [15], result-ing in hydrophobic interaction between the N-domainand the regulatory TnC-binding site [16]. This inter-action...