... Based on surface analysis, we propose a rigiddomain association for the N-terminal SEA domain with the back site of the proteinase domain.AbbreviationsHAI, hepatocyte growth factor activator ... extracellular matrix, it seems more likely that the SEA domain functions by orienting the active site cleft of DESC1 toward plasma and ⁄ or extracellular spaces and away from the cell surface and ... growth factors and proteinase inhibitors. Biol Chem 380, 473–483.17 Kataoka H, Uchino H, Asada Y, Hatakeyama K,Nabeshima K, Sumiyoshi A & Koono M (1997) Analy-sis of tissue factor and tissue...