... of pantoate bound in the ATP-binding pocket. Pantoatebinding to the ATP-binding site induced large changes in structure, mainlyfor backbone and side chain atoms of residues in the ATP bindingHXGH(34–37) ... [8,9]. One of the interesting features of the plant PSs is the presence of a conserved 24 residue insertion in the sequence [9].This sequence of amino acids, which is missing in the sequence of bacterial ... 7.5), in the presence of substrates(10 mm pantoate, ATP, and b-alanine), in the presence of protein stabilizers such as arginine, glutamate andproline [14–17], or even in the presence of detergents(Chaps...