... inhibitor, N-(R )-[ 2-( hydrox-yaminocarbonyl)-methyl ]-4 -methylpentanoyl-l-naphthyl-alanyl-l-alanine-2-aminoethyl amide (TAPI-1), but notby a mixture of inhibitors for serine, aspartic and cysteine ... small interfering RNA; TAPI-1, N-(R )-[ 2- (hydroxyaminocarbonyl)-methyl ]-4 -methylpentanoyl-L-naphthylalanyl-L-alanine-2-aminoethyl amide; tPA, tissue-type plasminogen activator.4810 FEBS Journal ... matrilysin and 6-aminohexanoic acid (e-aminocaproic acid) were fromWako Pure Chemical Industries (Osaka, Japan); the MMPsubstrates 3145v (Pyr-Gly-Arg-MCA) and 3105v (Boc-Glu-Lys-Lys-MCA) and the...