Breast cancer incidence and case fatality among 4 7 million women in relation to social and ethnic background: a population-based cohort study pdf

... check-point and in the control of apoptosis.BRCA1 can also enhance apoptosis via a pathwayinvolving H-Ras, mitogen-activated protein kinasekinase kinase 4, Jun N-terminal kinase, Fas ligand ⁄ Fas and ... hypoxia-induced changes in BRCA1 localization.TRAIL, but not hypoxia, induces apoptosis in breast cancer cellsAs our data suggested that hypoxia was stimulating a TRAIL signaling pathway and TRAIL ... apoptosis-inducing ligand-induced apop-tosis by blocking Bax translocation. Cancer Res 64, 40 78 40 81.15 Nagaraj N, Vigneswaran N & Zacharias W (20 07) Hypoxia inhibits TRAIL-induced tumor cell apoptosis:involvement...

... chromosome 7p12-13 and codes for a 170 kDa receptor tyrosine kinase. AllERBB proteins have four functional domains: anextracellular ligand-binding domain; a transmembranedomain; an intracellular tyrosine ... mul-tiple signalling pathways, including mitogen-activatedprotein kinase, phosphatidylinositol 3-kinase ⁄ AKT and the signal transducer and activator of transcription(STAT)3 and STAT5 pathways (Fig. ... tyrosine kinase domain; and a C-terminal regulatory domain [2]. The extracellulardomain is subdivided further into four domains. Thetyrosine kinase domain consists of an N-lobe and a C-lobe, and...

... TRX I AKX ANX meso BAXTotal numberof atoms1506 149 5 1586 1512 149 3 1518 148 5 144 8 1 47 1 1 348 13 94 1388 142 2 16 64 Atoms/residue 7. 88 7. 83 7. 97 7 .79 7. 70 7. 83 7. 82 7. 83 7. 74 7. 57 7.66 7. 67 7 .73 ... 48 .0 49 .1 50.3 48 .7 48 .2 46 .7 49 .5 49 .6 49 .6 48 .7 51.252.0 53 .4 48 .4 49.6 50.2 49 .6 49 .6Protein density 0.550 0. 545 0.556 0. 544 0. 541 0. 5 47 0. 549 0. 5 47 0. 549 0. 543 0. 548 0. 544 0. 5 47 0.5560. 548 ... b-strand A4 gives additionalhydrogen bonding with b-strand A5 and the extension ofb-strand B3 interacts with a b-strand B4. BAX also has a longer C-terminal b-strand A4 and a short additionalb-strand...

... sensitiv-ity analyses. For breast cancer and all cause mortality,we additionally adj usted for age at diagnosis of breast cancer and extent of breast disease (instead of FIGOstage). All analyses ... 94 12.0 24 7 .4 190 10.155 to 64 183 23.9 215 27 .4 71 21.9 46 9 25.065 to 74 277 36.2 238 30.3 138 42 .6 653 34. 8 75 to 84 1 84 24. 1 1 87 23.8 74 22.8 44 5 23 .7 85 and over 49 6 .4 52 6.6 17 5.2 118 ... endometrial cancer as cause of death in 37 cases and these patients were censored at date of death in themain analyses, and their inclusion as endometrial cancer deaths strengthened the association...

... harm or an increase in patient monitoring with nochange in vital signs and no harm noted. Moderate errors wereclassified as those causing an increase in patient monitoring, a change in vital ... but, in some cases, mayhave lead to an increase in monitoring but with no change in vital signs. There were four errors, however, that caused eitherpatient harm or increased monitoring and 34 interceptederrors ... (GEHealthcare, Anapolis, MD, USA) to the ICU but not on the gen-eral wards. The new system was introduced following a pro-gram of staff training and HWP was completely changed on a single day....

... treat-ment and potential links to data quality. This understand-ing provides insight into potential errors (bias and random error) related to data based on clinical examina-Acta Veterinaria Scandinavica ... agreed to participate after a shortintroduction. Only one veterinarian from each practicewas included. Anonymity was guarantied to promoteopenness and confidentiality.Acta Veterinaria Scandinavica ... data and decision mak-ing in relation to treatment of metritis and their motiva-tion to produce data. This information was condensedinto a 'model of understanding' that demonstrates...

... Onuma Kasukabe, Saitama 344 -0038, Japan (E-mail: satoshi.yamaguchi@chiyodakohan.co.jp) *3 Process Development and engineering Department, Cyiyodakohan Co.Ltd. 5-2-1 Ginza Chuo-ku, Tokyo 1 04- 8115, ... reactor with 8 lamps at flow rate 230 m3/h calculated by using the particle tracks data and Equation (4) ~ (7) , where refractive index:1.5 for quartz, 1.3 for water, assumed dirt factor of quartz ... UV-disinfection Reactor Validation by Computational Fluid Dynamics and Relation to Biodosimetry and Actinometry Kenichiro Deguchi1), Satoshi Yamaguchi2) and Hiroshi Ishida3) *1...