Báo cáo Y học: High pressure-induced changes of biological membrane Study on the membrane-bound Na+/K+-ATPase as a model system pdf
Báo cáo Y học: High pressure-induced changes of biological membrane Study on the membrane-bound Na+/K+-ATPase as a model system pdf
... High pressure-induced changes of biological membrane Study on the membrane- bound Na+/K+-ATPase as a model system Michiko Kato1, Rikimaru Hayashi1, Takeo Tsuda2and Kazuya Taniguchi21Division ... respectively. It was already shown that high concentration of Na+activates pyruvate kinasewithout K+[27]. The reaction was initiated by an addition of 1 lgenzyme.K+-activated phosphatase activity ... MPa or lower. The decreasedreaction rate of the Na+/K+-ATPasewithanincreaseinpressure can be rationalized based on a decrease in ¯uidity of the lipid bilayer with a concomitant decrease...
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Báo cáo y học: "High level expression of apoptosis inhibitor in hepatoma cell line expressing Hepatitis
... such as caspase-3, caspase-6, and caspase-7 are executioner caspases that remain dormant until the initiator caspases activate them by proteolysis [8]. The activated executioner caspases cleave ... gene array analysis. The up-regulation of cIAP2 was confirmed by the Northern Blot analysis. After the hybridization with the probe specifying cIAP2, cIAP2 RNA appeared as a special band located ... a cascade of intracellular cysteine proteases known as caspases. Caspases can be divided into two groups based on the length of their prodomain and substrate specificity. The initiator caspase...
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Báo cáo Y học: In vivo activation of plasma membrane H+-ATPase hydrolytic activity by complex lipid-bound unsaturated fatty acids in Ustilago maydis docx
... although the particular fatty acid may be different for each species,activation of the plasma membrane H+-ATPase byincreases in the unsaturation of the CLB-fatty acids is a physiological and relevant ... ithout ad ditions, as was the above mentioned parental strain as a wild-typecontrol.Plasma membrane purificationU. maydis plasma membranes were isolated and purifiedusing the aqueous two-phase ... pH, a nity to MgATP and constants for the inhibition by vanadate and erythrosin B remain unchanged.This all indicates that activation of plasma membrane H+-ATPase by unsaturated fatty a cids...
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Báo cáo khoa học: Channel-forming activities of peroxisomal membrane proteins from the yeast Saccharomyces cerevisiae pot
... orcarbohydrates [3]. A role for peroxisomal membrane as a permeabilitybarrier to solutes has been a matter of debate for morethan 40 years. Only recently was a ‘consensus’ reached on the idea ... estimated by analysis of the activity of marker enzymes for different organelles:peroxisomes (catalase), mitochondria (cytochrome coxidase) and lysosomes (acid phosphatase) (Fig. 1A) , as well as ... freely traverse the peroxisomal mem-brane. By contrast, detection under similar conditions of an aspartate aminotransferase reaction showed that the ‘total’ and ‘free’ activities of the enzyme...
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Báo cáo Y học: High affinity binding between laminin and laminin binding protein of Leishmania is stimulated by zinc and may involve laminin zinc-finger like sequences doc
... transmembrane glyco-protein on the surface o f Leishmania donovani that binds tolaminin, the major glycoprotein of ECM and BM [5].Detailed characterization has revealed that it may a ct as anadhesin ... using anti-LBP Igand secondary antibody also resulted in a 67-kDa band(lane 5) confirming the a uthenticity of the protein. Finally, the parasitic origin of the protein was demonstrated byimmunoprecipitating ... is a prerequisite formany types of infections. Diseases such as leishmaniases areis generally initiated when sand y, the vector, regurgitatespromastigote form of the parasite at the time of...
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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... technology assay (PCTKryptor®, B.R .A. H.M.S. AG, Hennigsdorf, Germany). The assay has a detection limit of 0.02 μg/L and functionalassay sensitivity of 0.06 μg/L.Statistical analysisDevelopment and ... into the pathophysiology and prognosis of a disease process. As a quantifiable tool it facilitates risk stratification and moni-toring of therapy as a surrogate outcome measure. In the future, a ... promising approach. As a limitation of this study, our findings may notunconditionally be applied to a general LRTI populationbecause of selection bias in regard to exclusion criteria of the underlying...
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Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... to assess the impact of ADHD symptoms on the lives of children andtheir families at baseline and study endpoint. Satisfaction with MTS use was assessed via a Medication Satisfaction Survey (MSS)at ... ongoing AEs.Health-related quality of life and medication satisfaction measures As secondary objectives of this study, caregiver-reportedHRQL and medication satisfaction were assessed using the ADHD ... medi-cation on their child's attention. The majority of caregiv-ers (93.1%) indicated a high level of satisfaction with the duration of effect of the study medication on their child'sADHD...
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Báo cáo y học: "An unusual case of gout in the wrist: the importance of monitoring medication dosage and interaction. A case report"
... made aware that dosage changes of certaindrugs may precipitate a gouty attack as well as bringing totheir attention the effect of aspirin on serum urate levels.Awareness of radiographic changes ... dosages may precipitate an attack. Awareness of radiographic changes associated with gout is still of importance although these changes are notseen as frequently as they have been in the past ... wrist pain possiblyprecipitated by a medication dosage increase as well as medication interactions.Case presentation A 77 year old male was treated at a chiropractic clinic forlow back pain resulting...
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Báo cáo y học: "Clinical review: Treatment of new-onset atrial fibrillation in medical intensive care patients – a clinical framework"
... tachycardia, and by tachycardiomyopathy[8,44]. Tachycardiomyopathy can occur as soon as 24 hoursafter the start of AF [44].Conclusion on morbidityIn all patient categories, AF is associated with ... improvesurvival?There are few data on the effect of treatment of AF on mortalityin ICU patients. A meta-analysis in non-ICU patients showedthat class IA, class IC and class III antiarrhythmic agents areequally ... AF and mortality being a result of disease severity might be one of the explanations for the association [10]. A causal mechanism they have in common(for example, inflammation) might be another...
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Báo cáo y học: " High blood pressure, antihypertensive medication and lung function in a general adult population"
... pressure and antihy-pertensive medication are highly correlated. A detailedanalysis of antihypertensive medication indicates that BBLmedication and not any other antihypertensive medicationis associated ... drawn from the target population consisting of allGerman residents of the region aged 25 to 74 years. Of all 4261 participants of the S4 baseline study, 3080also participated in the 7-year ... this analysis isto determine whether hypertension as well as antihyper-tensive medication has an adverse effect on lung functionin a general adult population.Methods Study populationTheKORAF4studyisafollow-upoftheKORAS4 study, ...
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