Báo cáo khoa học: Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate pathway based upon kinetic and genetic evidence doc

... v16ðA10ÞTracing13C in the pentose phosphate pathway R. J. Kleijn et al.4982 FEBS Journal 272 (2005) 4970–4982 ª 2005 FEBS Revisiting the 13C-label distribution of the non-oxidative branch of the pentose phosphate ... kinetic mechanism of the enzymes transketolase (EC 2.2.1.1) and transaldolase (EC 2.2.1.2). Based upon the ping-pong mechanism, the traditional reactions of the nonoxida-tive branch of the pentose ... that the newly proposed stoichiometric model allowsstudy of the effect of isoenzymes on the 13C-label distribution in the non-oxidative branch of the pentose phosphate pathway by extending the...

Báo cáo khoa học: Revisiting the prediction of protein function at CASP6 potx

... subset was made of only 11 targets and included 24, 7, 2 and 1 GOF, GOP, GOC and BINDannotations, respectively. Because of the sparseness of the data, the analysis was limited to GOF functionalassignments ... to the assessor.After the experiment was concluded, we revisited the data collected and reassessed the results, taking intoaccount the methods used. We took advantage of the knowledge of the ... was either modiﬁed or deletedbetween the end of 2004 and the end of 2005 (supple-mentary material, Table S1). In the same period, the number of non-annotated targets decreased by 8, 6, 2and...

Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf

... deﬁne the core of the protein’s Nstate [21]. For the T domain, these were the center of TH5 and TH8, and the N-terminal half of TH9. Alla-helices (TH1, 3, 4, 5’, 6, 7 and the remaining parts of TH5 ... in the N state and the evolution of the overallstructure of the protein in the MG state. This degree of resolution is unprecedented for the T domain of the diphtheria toxin. Three levels of ... In the case of the T domain, the MGstate corresponds to the functional state, which initi-ates the translocation of the catalytic domain. Here, the data allowed identiﬁcation of the core of the...

Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

... speciﬁcity of the interaction. The lack of effect of the diphosphate nucleotide indicates that,following inorganic phosphate release, the ADP-boundABCG2R482Gisoform adopts a conformation capable of ... evidence for an interaction between the two domains is the ability of numerous substrates and modulators of ABCG2 (and the R482G isoform)to stimulate the rate of ATP hydrolysis [21,24,25],albeit ... because of its higher potency. Figure 1B dem-onstrates the ability of the nucleotides to reduce the fraction of [3H]daunomycin bound to ABCG2R482G.In the presence of AMP, the binding of [3H]daunomycinremained...

Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-speciﬁc alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt

... RT-PCR to study the tissue-speciﬁc use of each promoter. We show the translation initiation site of isoform 2 and different intracellular distribution of isoforms 1 and 2, and discuss the regulatory ... secreted from cells. Hence, the pro-moter use of the KLK11 gene appears to link to the splicing pathway of KLK11 mRNAs and to regulate the trafﬁcking of KLK11 isoforms in the trans-Golginetwork. ... exons 1b and 1c. Tran-script 2 encoded another type of KLK11, isoform 2,despite the presence of exon 1c. The secretory path-ways of KLK11 isoforms appeared to differ, althoughboth isoforms...

Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identiﬁcation of oscillophores ppt

... each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence path of order pÕ equal those of the ... The absolute magnitude of acombined autoinfluence path is the product of all the ratesdivided by the product of all the concentrations of itsspecies. Therewith the c oefficient of o rder p of ... containparallel and antiparallel arrows). The sign of that elementtherefore depends on the both the sign and the magnitudes of these influen ce paths (see below). If all its i nfluence pathsare positive, the...

Tài liệu Báo cáo khoa học: "Exploiting Readymades in Linguistic Creativity: A System Demonstration of the Jigsaw Bard" docx

... the scale of the Bard’s genera-tivity, and the quality of its insights.5 Empirical Evaluation The vastness of the web, captured in the large-scale sample that is the Google ngrams, means the Jigsaw ... instances of the patterns“as ADJ and * as” and “as * and ADJ as” fromGoogle, noting the combinations that are found and their frequencies. These frequencies provide linkweights for the Hofstadter-style ... recognized. In the vein of Veale and Hao (2007), we use the Google API toharvest the elements of this SlipNet.16We hypothesize that the construction “as ADJ1 and ADJ2 as” shows ADJ1 and ADJ2...

Tài liệu Báo cáo khoa học: "A Method for Correcting Errors in Speech Recognition Using the Statistical Features of Character Co-occurrence" pptx

... improving the understanding of the recognition results. On the other hand, there were four level-down cases. Three of these cases were caused by the misdetection of errors in the SSC procedure. The ... arbitrary candidates, when one of their Error-Parts includes the other, and their frequencies are the same value, the candidate whose Error-Part includes the other is accepted. Condition of Inclusion-2: ... In all other cases, go to the step for a middle. Here, P1 and P2 denote the start and end positions of an error-block, and L denotes the length of the input string. Step 2: Take the string...

Báo cáo khoa học: Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis docx

... between the cytoplasmic surfaces of myoblast and myotube NPCs and a correlation between the copy number of Nup358 and the NPC structure. Furthermore, small interfering RNA-mediated depletion of Nup358 ... attention. The general architecture of the NPC is evolutionarily con-served in all eukaryotes and consists of ﬁlaments on the cytoplasmic surface and spoke rings and a basket-like structure on the ... S2C). The upper rim diameter of the NPC increased by approxi-mately 9 nm during myotube formation, whereas the outer diameter and the height of the NPC were notsigniﬁcantly changed. Thus, the...

Báo cáo khoa học: "Who, What, When, Where, Why? Comparing Multiple Approaches to the Cross-Lingual 5W Task" pptx

... from the parser to map parser constituents to the 5Ws. First the Who, When, Where and Why were ex-tracted, and then the remaining pieces of the sen-tence were returned as the What. The goal ... developed for the monolingual 5W task and not modified to handle MT. They used hand-crafted rules on the output of the latent annotation parser to extract the 5Ws. English-function used the function ... line. The What question was the hardest, since it requires two pieces of information (the predicate and object). The When, Where and Why ques-tions were easier, since they were null most of the...

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