Báo cáo khóa học: Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain pdf
Báo cáo khóa học: Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain pdf
... Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain Katsuhiko Minoura1, Tian-Ming Yao1, Koji ... of the four -repeat microtubule-binding domain (MBD) moiety in the entire human tau protein (A) and the aminoacid sequence of each repeat (B). The regions from the first to the fourth repeat fragments ... difference between the second and third repeat fragments in the tau MBD in terms of (a) self- and seeded-aggregations and (b) the conformation induced byTFE solution. Knowledge of these different conformational behaviors...
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Báo cáo khoa học: Spatio-temporal distribution of fatty acid-binding protein 6 (fabp6) gene transcripts in the developing and adult zebrafish (Danio rerio) pptx
... according to the tissue from which they were initially isolated, e.g. liver-type fatty acid-binding protein (L-FABP), brain-typefatty acid-binding protein (B-FABP), intestinal-typefatty acid-binding ... lipid-binding protein, intesti-nal 15 kDa protein, ileal bile acid-binding protein and gastrotropin, reflecting the speculations of authors onits intracellular function(s). In vitro binding assaysrevealed ... anintense hybridization signal in the distal region of the intestine (Fig. 6, 1A) and in the adrenal homolog of the kidney (Fig. 6, 1D). Less-intense hybridization sig-nals were observed in the...
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Báo cáo khoa học: Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm pdf
... areindicated by underlines. The similarity between SIK1 and SIK2 in domain 3A, the N-terminal half of domain 3, is higher thanthat in domain 3B, the C-terminal half.(C) The intracellular distribution ... localized lessinthenucleusthanthewild-typeSIK1(seethedifference between the first and second panels in Fig. 4C). On the other h and, Chimera 2, SIK2, in which domain 3B hadbeen replaced with the RK-rich ... arereplaced with other residues in the corresponding regionof SIK2. To examine whether or not the lower similarity in domain 3 B between the two isoforms contributes to the difference in their intracellular...
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Báo cáo khoa học: Missense mutations as a cause of metachromatic leukodystrophy Degradation of arylsulfatase A in the endoplasmic reticulum potx
... recognizing the early epitopes A and B and not with those recognizing the late epitopes C, E and F. Interestingly, mutant ASAs of these two groupsare completely retained in the ER. Retention in the ER ... causeASA deficiency. In about half of the examined cases the mutant enzymes are retained in the ER [2,9,10], in the other half, enzymes can leave the ER and be degradedafter arrival in the lysosome ... folding does notproceed in a vectorial, domainwise process from the Nterminus to the C terminus. Instead, folding occurs viaintermediates with disulfide bridges involving distantparts of the...
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Báo cáo khoa học: Evaluation of potential regulatory elements identi®ed as DNase I hypersensitive sites in the CFTR gene doc
... a proportionate increase in the intensity of the DHS fragments in the control samples. In Fig. 7A the forskolin-treated chromatin shows a relative increase in the intensity of the DHS10a (1716 ... introns16 and 17 are of similar intensity but the DHS in intron 18 isless evident ( Fig. 5B). In contrast, the DHS in intron 18 ismore prominent than those in introns 16 and 17 (Fig. 5A) in chromatin ... particular interest were the DHS in introns 2 and 18,which w ere s trongly evident in Capan1 in comparison toCaco2 chromatin (Fig. 4). The DHS in introns 2 and 3 weredetected as subbands of 4.5 and...
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Báo cáo khoa học: Isolation of a putative peroxidase, a target for factors controlling foot-formation in the coelenterate hydra docx
... with the tentacles (t) at the distal, and the foot (f) at the proximal end of the animal. The arrow pointsat peroxidase containing cells lying in the ectoderm of the foot. The diaminobenzidine-stained ... after 35 min by four or five washes of the gel in H2O. The arrows indicate the stained bands in the gel. I is the majorperoxidase activity of hydra residing in the foot of the animal, IIindicates ... diam-inobenzidine and H2O2. As can be seen in Fig. 5A, a major and a minor activity exist in the animal. Only the majoractivity (band I) is present in the feet of the animals.Therefore, band...
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Báo cáo khoa học: Transcriptome profiling analysis reveals multiple modulatory effects of Ginkgo biloba extract in the liver of rats on a high-fat diet pdf
... Acacb,Acbd6 (acyl-CoA-binding domain containing 6), Scd2(stearoyl-CoA desaturase 2) or associated genes,Sorbs3 (sorbin and SH3 domain containing 3) and Etnk1_predicted (ethanolamine kinase 1) were down-regulated ... reticulumprotein that blocks the processing of sterol regulatoryelement-binding proteins (SREBPs) by binding toSREBP cleavage-activating protein, thus preventing the latter from escorting SREBPs to the ... prevented the harm caused by an HFD. In addition, we found no significant alterations in the levels of alanine aminotransferase, aspartate amino-transferase or creatinine kinase in either group...
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Báo cáo khoa học: Quenched hydrogen ⁄deuterium exchange NMR characterization of amyloid-b peptide aggregates formed in the presence of Cu2+ or Zn2+ ppt
... assembled, the N-terminal metal-binding region of the peptide will be in close proximityto both the C-terminal and turn residues, possiblyinterfering with these regions. This explains how analtered ... assembly and pinpointing the mechanism by which metals guide the path of aggre-gation away from the fibrillar trail. The present investigation assessed how the growth and architecture of Ab(1–40) and ... thatAb in complex with either Cu2+or Zn2+can attain an aggregation-proneb-strand–turn–b-strand motif, similar to the motif found in fibrils, butwhere the metal binding to the N-terminal region...
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Tài liệu Báo cáo khoa học: "Different Structures for Evaluating Answers to Complex Questions: Pyramids Won’t Topple, and Neither Will Human Assessors" docx
... turn and marks the appearance of the nuggets. An an-swer string contains a nugget if there is a conceptualmatch; that is, the match is independent of the partic-ular wording used in the system’s ... according to the vital/okay judgments of assessor a. The differ-ences between the pyramid F-score and the macro-averaged binary F-score correspond to the distinc-tion between micro- and macro-averaging ... present in a “good” an-swer. Okay nuggets may contain interesting infor-mation, but are not essential. In the second step, the same assessor who cre-ated the nuggets reads each system’s output in...
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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx
... reinforce the argument that the basic domain should be exposed at the surface of the Tat-containing recombinant proteins and call other reasonsto explain the differences in the mechanism of internaliza-tion ... routes for the Tat CPP and the Tat protein.What might be the reasons underlying the observeddifferences in cellular uptake between the Tat CPP and the GST±Tat±GFP protein, that both contain the same ... utations in the basic domain of T at abolished uptakeof these constructions [22] thus indicating that this domain i sessential for binding to the receptor. The present workaimed at de®ning whether...
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